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Dosage for coadministering drug and percutaneous absorption enhancer

  • US 4,379,454 A
  • Filed: 02/17/1981
  • Issued: 04/12/1983
  • Est. Priority Date: 02/17/1981
  • Status: Expired due to Term
First Claim
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1. A unit dosage form for coadministering a drug and a percutaneous absorption enhancer to a predetermined area of unbroken skin of a patient for a predetermined time period, the dosage form comprising a body(a) having a basal surface(i) of area at least about equal to the area of skin,(ii) that is adapted to contact the area of skin over the time period, and(iii) via which the drug and enhancer are presented to the area of skin for absorption thereby;

  • (b) containing a supply of the drug that communicates with the basal surface to provide drug at the basal surface over the time period such that over a substantial portion of the time period the amount of drug provided is in excess of that which the area of skin is able to absorb;

    (c) containing a supply of the percutaneous absorption enhancer that communicates with the basal surface over said time period; and

    (d) including means for maintaining the rate at which the enhancer is provided at the basal surface substantially constant over a substantial portion of the time period, the rate being(i) below the maximum rate the area of skin is able to absorb, and(ii) sufficient to increase the permeability of the area of skin to the drug such that the drug is absorbed thereby at a rate that provides a therapeutically effective level of the drug in the bloodstream of the patient.

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