Method for low pressure filtration of plasma from blood

• US 4,381,775 A
• Filed: 08/18/1980
• Issued: 05/03/1983
• Est. Priority Date: 02/05/1980
• Status: Expired due to Term

• Current Assignee: Asahi Medical Co. Ltd. (Asahi Kasei Corporation)
• Original Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Inventors: Malchesky, Paul S., Nose', Yukihiko
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): Wallen, T. J.
• Application Number:
  US06/179,224
• Time in Patent Office: 988 Days
• Field of Search: 128/213 A, 128/213 R, 128/214 R, 210/23 F
• US Class Current: 604/6.04
• CPC Class Codes: A61K 35/16 Blood plasma; Blood serum umbilical cord blood A61K35/51
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: B01D 61/147 Microfiltration
• CPC Class Codes: B01D 63/02 Hollow fibre modules

Abstract

A method for carrying out separation of plasma from whole blood, in which whole blood is passed through a filtration membrane means of a material suitable for separating plasma from whole blood and having a pore size from 0.1 to 0.6 microns at positive pressure differential across the membrane in a range up to just below 50 mm Hg. This provides an increased flow as compared to the flow obtained with higher pressures.

Claims

1. A method of separating plasma from whole blood, comprising the step of:

directing a flow of whole blood across one face of a filtration membrane means which is made of a material suitable for separating plasma from whole blood and having a pore size from 0.1 to 0.6 microns, said flow being at a flow velocity of from 5 to 1500^cm /min and being at a depth sufficient for separating plasma from the flow of blood, and at the same time generating a positive pressure differential across said membrane up to just below 50 mm Hg. for forcing plasma through the membrane, and collecting the plasma separated by the membrane.

2. A method as claimed in claim 1 in which the step of generating a pressure differential across said membrane comprises generating a pressure in a range from about 8.5 mm Hg. to just below 50 mm Hg.

3. A method as claimed in claim 1 in which the pressure generating step comprises generating a pressure in a range of from about 20 to about 40 mm Hg.

4. A method as claimed in claim 1 in which said membrane means is a film type membrane.

5. A method as claimed in claim 1 in which said membrane means is a hollow fiber membrane.

6. A method as claimed in claim 1 in which said membrane means is a hollow fiber membrane of hydrophilic material.