Automatic ultrafiltration control system

• US 4,381,999 A
• Filed: 04/28/1981
• Issued: 05/03/1983
• Est. Priority Date: 04/28/1981
• Status: Expired due to Term

• Current Assignee: Gambro, Inc. (DaVita Incorporated)
• Original Assignee: COBE Laboratories Incorporated (Terumo Corporation)
• Inventors: Hlavinka, Dennis J., Johnson, Steven H., Boucher, Terry D., Kenshalo, Richard M.
• Primary Examiner(s): Adee, John
• Application Number:
  US06/258,379
• Time in Patent Office: 735 Days
• Field of Search: 210/96.2, 210/637, 210/645-647, 210/741, 210/739
• US Class Current: 210/637
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1658 Degasification
• CPC Class Codes: A61M 1/169 using chemical substances
• CPC Class Codes: A61M 1/341 by measuring the filtrate rate or volume
• CPC Class Codes: A61M 1/3413 Diafiltration
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: B01D 61/145 Ultrafiltration
• CPC Class Codes: B01D 61/22 Controlling or regulating
• CPC Class Codes: B01D 61/243 Dialysis

Abstract

A system for supplying fluid for a fluid flow transfer device and achieving target ultrafiltration fluid losses by automatically, periodically monitoring the ultrafiltration rate and transmembrane pressure, computing the transmembrane pressure necessary to achieve the target fluid loss by the end of a session, and adjusting the transmembrane pressure to the computed value.

Claims

1. A method of automatically achieving a target amount of ultrafiltration in a fluid flow transfer device having a first fluid flowing past one surface of a semipermeable membrane and a second fluid flowing past the other surface by the end of a specific overall time period, said method comprising

supplying said first fluid to said fluid flow transfer device,

removing said first fluid from said fluid flow transfer device,

generating electrical ultrafiltration rate signals indicative of the difference of the flowrate of the first fluid entering said device and the flowrate of the first fluid leaving said device,

generating electrical first fluid pressure signals indicative of the pressure of said first fluid in said device with a first fluid pressure sensor,

generating electrical second fluid pressure signals indicative of the pressure of the other liquid flowing through said device with a second fluid pressure sensor,

adjusting one of said pressures of said fluids in response to electrical pressure adjustment signals,

generating electrical target signals indicative of said target amount of ultrafiltration and said specific time period at control panel means and supplying them to ultrafiltration control means, and

automatically periodically receiving said first and second fluid pressure signals and said ultrafiltration rate signals, computing a coefficient for describing the relationship between the ultrafiltration rate and the difference of pressures of the first and second fluids (the transmembrane pressure), and producing said pressure adjustment signals at said ultrafiltration control means,

said adjustment signals indicating transmembrane pressure corresponding to the desired ultrafiltration rate based upon the most recently calculated value of said coefficient, whereby the actual ultrafiltration rate results in achieving the target fluid loss by the end of said overall time period even if the relationship between the fluid pressures and ultrafiltration rate changes during said specific overall period.

2. The method of claim 1 wherein said ultrafiltration control means initially produces an initial pressure adjustment signal to achieve a predetermined transmembrane pressure, receives signals from said ultrafiltration measuring means indicating the ultrafiltration rate resulting from said predetermined transmembrane pressure, computes said coefficient, computes the desired ultrafiltration rate for the remainder of the period taking into account the difference between the rate of ultrafiltration during said initial period and the average ultrafiltration rate necessary to achieve said target amount in said overall period, and produces adjustment signals to create a transmembrane pressure resulting in said desired ultrafiltration rate.

3. The method of claim 2 wherein said ultrafiltration control means receives said pressure signals and produces said pressure adjustment signals between the time when it periodically receives said ultrafiltration rate and pressure signals, and computes said coefficient to maintain said transmembrane pressure even when said second fluid pressure changes between periodic measurements of ultrafiltration rates and computation of said coefficients.

4. The method of claim 1 wherein said device is a dialyzer, said first fluid is dialysate, said second fluid is blood, and in computing said coefficient and producing said pressure adjustment signals, the oncotic pressure is taken into account, said relationship being described by the following formula:

the ultrafiltration rate equals the ultrafiltration coefficient, K_UF, times the difference of the transmembrane pressure and the oncotic pressure.

5. The method of claim 3 wherein said ultrafiltration control means responds to signals from said control panel means after the beginning of said overall time period to adjust said target amount and/or the length of said overall time period.

6. The method of claim 2 wherein said control panel means visually displays the fluid removed so far, the remaining time in said overall time period, said target amount, and the average rate of ultrafiltration in response to display signals from said ultrafiltration control means, and said ultrafiltration control means continuously provides signals to change said first two visual displays throughout said overall time period.

7. The method of claim 3 wherein said device is a dialyzer, said first fluid is dialysate, said second fluid is blood, and in computing said coefficient and producing said pressure adjustment signals, the oncotic pressure is taken into account, said relationship being described by the following formula:

the ultrafiltration rate equals the ultrafiltration coefficient, K_UF, times the difference of the transmembrane pressure and the oncotic pressure.

8. The method of claim 7 wherein said ultrafiltration control means responds to signals from said control panel means after the beginning of said overall time period to adjust said target amount and/or the length of said overall time period.

9. The method of claim 8 wherein said control panel means visually displays the fluid removed so far, the time remaining in said overall time period, said target amount, and the average rate of ultrafiltration in response to display signals from said ultrafiltration control means, and said ultrafiltration control means continuously provides signals to change said first two visual displays throughout said overall time period.