Radiation-induced thermoacoustic imaging

• US 4,385,634 A
• Filed: 04/24/1981
• Issued: 05/31/1983
• Est. Priority Date: 04/24/1981
• Status: Expired due to Term

• Current Assignee: Arizona State of University, Optosonics Inc., Teletherm Corporation
• Original Assignee: University of Arizona Foundation (University of Arizona)
• Inventors: Bowen, Theodore
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): Yanulis, George
• Application Number:
  US06/257,166
• Time in Patent Office: 767 Days
• Field of Search: 73/355 R, 73/363, 73/368, 73/601, 73/602, 73/643, 128/653, 128/659, 128/660, 128/661, 128/664, 128/736
• US Class Current: 600/407
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: G01N 2291/02491 Materials with nonlinear acoustic properties
• CPC Class Codes: G01N 2291/02872 Pressure
• CPC Class Codes: G01N 2291/02881 Temperature
• CPC Class Codes: G01N 2291/0427 Flexural waves, plate waves, e.g. Lamb waves, tuning fork, cantilever
• CPC Class Codes: G01N 29/2418 using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics photoacoustic cells G01N21/1702; measuring characteristics of vibrations by using radiation-sensitive means G01H9/00; acousto-optical conversion techniques for short-range imaging G01S15/8965; sound-producing devices using laser bundle G10K15/046
• CPC Class Codes: G01N 29/449 Statistical methods not provided for in G01N29/4409, e.g. averaging, smoothing and interpolation
• CPC Class Codes: G01S 15/8906 Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
• CPC Class Codes: G01S 15/899 Combination of imaging systems with ancillary equipment

Abstract

The acoustic wave generated by sudden thermal stress is used to obtain information non-invasively on the composition and structure of the stressed body. One or more acoustic transducers (1 and 1'"'"') are coupled with the surface of the body to intercept the acoustic wave and generate a corresponding electrical signal. The sudden thermal stress is induced by a pulse of radiation which deposits energy causing a rapid, but very small, rise of temperature. The radiation may be ionizing radiation, such as high energy electrons, photons (X-rays), neutrons, or other charged particles. The radiation may also be non-ionizing radiation, such as RF(2) and microwave electromagnetic radiation (3) and ultrasonic radiation (4). The electrical signal from the acoustic transducer (1) is amplified (5) and supplied to a digitizer (6), which provides a continuous stream of digital words corresponding to samples of the amplified signal. Because in most situations of practical interest the S/N ratio of a single pulse is much less than unity, it is necessary to signal-average the signals from many successive pulses. This is accomplished with a minicomputer or data processor ( 8) suitably interfaced (7) with the digitizer. The resulting data can then be suitably displayed as an image on a CRT display (9) or plotted or numerically printed out.

Claims

1. A method of radiation-induced thermoacoustic imaging to non-invasively detect the composition and structure of a body, comprising the steps of

inducing within a volume under investigation in said body a sudden thermal stress by a pulse of radiation which deposits energy causing a rapid, but very small, rise in temperature throughout said volume, and

receiving the thermoacoustic signal emitted from within said volume as a result of the induced sudden thermal stress, thereby producing an image of inhomogenieties within said volume.

2. The method of claim 1 further comprising the step of signal-averaging the received signals produced by many successive pulses of radiation.

3. The method of claims 1 or 2 wherein the step of inducing a sudden thermal stress is performed with a pulse of ionizing radiation.

4. The method of claims 1 or 2 wherein the step of inducing a sudden thermal stress is performed with a pulse of non-ionizing radiation.

5. The method of claim 2 further comprising the step of displaying the signal-averaged signals to produce image features of the composition and structure of said body.

6. A method of non-invasive thermoacoustic imaging of soft-tissue regions in humans and animals, comprising the steps of

coupling at least one acoustic transducer with the surface of a region to be investigated,

inducing within said region sudden thermal stresses by a series of pulses of radiation which deposit energy causing rapid, but very small, rises in temperature throughout said region,

receiving the thermoacoustic signals emitted from within said region as a result of the induced thermal stresses, and

signal-averaging the received signals produced as a result of the induced sudden thermal stresses, thereby producing an image of inhomogenieties within said region.

7. The method of claim 6 comprising the step of displaying the signal-averaged signals to produce image features of the composition and structure of said region.

8. The method of claim 6 wherein the step of coupling is performed by coupling two or more acoustic transducers with the surface of said region to be investigated, each of said transducers being positioned about the periphery of said region and the receiving beam patterns of all of said transducers being on the same place.

9. The method of claim 6 wherein the step of inducing is performed so that the rise in temperature is between 10^-8°

and 10^-4°

C.

10. Apparatus for non-invasively detecting the composition and structure of a body by radiation-induced thermoacoustic imaging, comprising:

means for inducing within a volume under investigation in said body a sudden thermal stress by a pulse of radiation which deposits energy causing a rapid, but very small, rise in temperature throughout said volume, and

means for receiving the thermoacoustic signal emitted from within said volume as a result of the induced sudden thermal stress, thereby producing an image of inhomogenieties within said volume.

11. The apparatus of claim 10 wherein said means for inducing a sudden thermal stress includes a source of ionizing radiation.

12. The apparatus of claim 11 wherein the ionizing radiation is an electron beam.

13. The apparatus of claim 11 wherein the ionizing radiation is a beam of photons.

14. The apparatus of claim 13 wherein the beam of photons is an x-ray beam.

15. The apparatus of claim 11 wherein said ionizing radiation is a beam of neutrons.

16. The apparatus of claim 11 wherein said ionizing radiation is a beam of charged particles.

17. The apparatus of claim 10 wherein said means for inducing a sudden thermal stress includes a source of non-ionizing radiation.

18. The apparatus of claim 17 wherein said non-ionizing radiation is RF radiation.

19. The apparatus of claim 17 wherein said non-ionizing radiation is microwave radiation.

20. The apparatus of claim 17 wherein said non-ionizing radiation is ultrasonic radiation.

21. The apparatus of claim 10 further comprising means for signal-averaging the received signals produced by many successive pulses of radiation.

22. The apparatus of claim 21 wherein said means for signal-averaging comprises:

digitizer means connected to said means for receiving and receiving an analog signal therefrom, said digitizer means sampling said analog signal at a high rate and providing at its output a digital word corresponding to each analog sample, and

computer means connected to said digitizer means and receiving the digital words therefrom, said computer means computing an average of said digital words.

23. The apparatus of claim 21 further comprising display means for displaying the signal-averaged signals to produce image features of the composition and structure of the body.

24. Apparatus for non-invasively imaging soft-tissue regions in humans and animals by means of thermoacoustic imaging, comprising:

at least one acoustic transducer coupled with the surface of a region to be investigated,

means for inducing within said region sudden thermal stresses by a series of pulses of radiation which deposit energy causing rapid, but very small, rises in temperature throughout said region,

means for receiving the thermoacoustic signals emitted from within said region as a result of the induced thermal stresses, and

means for signal-averaging the received signals produced as a result of the induced sudden thermal stresses, thereby producing an image of inhomogenieties within said region.

25. The apparatus of claim 24 wherein said means for inducing a sudden thermal stress includes a source of ionizing radiation.

26. The apparatus of claim 24 wherein said means for inducing a sudden thermal stress includes a source of non-ionizing radiation.

27. The apparatus of claim 24 further comprising display means for displaying the signal-averaged-signals to produce image features of the composition and structure of said region.