Rapid diagnostic agents
First Claim
1. A diagnostic agent for the rapid detection of blood in excretions and body fluids, which diagnostic agent consists essentially of a filter paper support simultaneously impregnated with(1) a chromogenic indicator selected from the group consisting of guaiac and chromogenic phenylamino compounds and capable of color change in the simultaneous presence of peroxidase-active hemoglobin present in blood and of peroxide solution separately applied to said diagnostic agent for development thereof, and(2) a resin selected from the group consisting of acrylic resins, methacrylic resins, and combinations thereof, said chromogenic indicator and resin being distributed uniformly or homogeneously throughout said filter paper, and said resin being present in an amount effective to reduce color change reactions prior to development and to promote the persistence of developed color while not interfering with chromatographic transport of the developed reagent.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to diagnostic agents for the rapid diagnostic detection of blood in excretions and body fluids, consisting essentially of a solid support which is charged with a chromogenic substance as indicator and impregnated with an acrylic and/or methacrylic resin.
14 Citations
5 Claims
-
1. A diagnostic agent for the rapid detection of blood in excretions and body fluids, which diagnostic agent consists essentially of a filter paper support simultaneously impregnated with
(1) a chromogenic indicator selected from the group consisting of guaiac and chromogenic phenylamino compounds and capable of color change in the simultaneous presence of peroxidase-active hemoglobin present in blood and of peroxide solution separately applied to said diagnostic agent for development thereof, and (2) a resin selected from the group consisting of acrylic resins, methacrylic resins, and combinations thereof, said chromogenic indicator and resin being distributed uniformly or homogeneously throughout said filter paper, and said resin being present in an amount effective to reduce color change reactions prior to development and to promote the persistence of developed color while not interfering with chromatographic transport of the developed reagent.
-
2. A diagnostic agent as in claim 1 wherein said resin is an anionic acrylic resin, an anionic methacrylic resin, or a combination thereof.
-
3. A diagnostic agent as in claim 1 wherein said resin is a copolymer of a member selected from the group consisting of acrylic acid and methacrylic acid with a member selected from the group consisting of acrylic acid esters and methacrylic acid esters of C1 -C3 alcohols, in a weight ratio from 1:
- 4 to 2;
1.
- 4 to 2;
-
4. A diagnostic agent as in claim 1 wherein said resin is a copolymer of methacrylic acid and ethyl acrylate.
-
5. A diagnostic agent as in claim 4 wherein said copolymer comprises methacrylic acid and ethyl acrylate in a weight ratio of 1:
- 1.
Specification
-
- Resources
-
Current AssigneeROHM GmbH Darmstadt Germany
-
Original AssigneeROHM Co., Ltd.
-
InventorsLehmann, Klaus, Kraemer, Dieter, Hartl, Roland
-
Primary Examiner(s)Turk, Arnold
-
Application NumberUS06/300,899Time in Patent Office642 DaysField of Search23/230 B, 23/931, 23/932, 252/408, 422/56-58, 436/66, 436/904US Class Current422/420CPC Class CodesC12Q 1/28 involving peroxidaseG01N 33/725 using peroxidative activityY10S 436/904 Oxidation - reduction indic...
