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Pharmaceutical agents for the treatment of sickle cell disease

  • US 4,390,526 A
  • Filed: 06/06/1980
  • Issued: 06/28/1983
  • Est. Priority Date: 06/21/1979
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition for preventing the sickling of erythrocytes during sickle cell crises, and for desickling of sickle cells of patients afflicted by sickle cell disease, comprising a pharmaceutical excipient, and, as active ingredient, an effective amount of the formula ##STR3## wherein R1 is a residue selected from the group consisting of naturally occurring and modified amino acids and from peptides containing said amino acids;

  • n is an integer of 1 to 5; and

    R2 is selected from the group consisting of unsubstituted thienyl, morpholine, pyridine, and pyrrolidone rings.

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