Adhesive compositions

• US 4,393,080 A
• Filed: 12/24/1981
• Issued: 07/12/1983
• Est. Priority Date: 12/24/1981
• Status: Expired due to Term

• Current Assignee: ER Squibb & Sons LLC (Bristol-Myers Squibb Company)
• Original Assignee: E R Squibb & Sons Incorporated
• Inventors: Pawelchak, John M., LaVia, Anthony L., Chen, James L., Cryan, John G.
• Primary Examiner(s): Phynes, Lucille M.
• Application Number:
  US06/334,284
• Time in Patent Office: 565 Days
• Field of Search: 523/111, 523/118, 524/17, 524/22, 524/37, 524/55, 428/424.2, 428/492, 428/516, 428/355-356, 428/447, 428/451, 428/476.6, 428/478.2, 428/520, 525/389, 128/283, 3/1
• US Class Current: 428/355.00R
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 2400/14 Adhesives for ostomy devices
• CPC Class Codes: C09J 7/21 Paper; Textile fabrics
• CPC Class Codes: C09J 7/38 Pressure-sensitive adhesives [PSA]
• CPC Class Codes: Y10T 428/2852 Adhesive compositions
• CPC Class Codes: Y10T 428/2857 including metal or compound thereof or natural rubber
• CPC Class Codes: Y10T 428/2883 including addition polymer of diene monomer [e.g., SBR, SIS, etc.]
• CPC Class Codes: Y10T 428/2887 including nitrogen containing polymer [e.g., polyacrylonitrile, polymethacrylonitrile, etc.]
• CPC Class Codes: Y10T 428/2896 including nitrogen containing condensation polymer [e.g., polyurethane, polyisocyanate, etc.]
• CPC Class Codes: Y10T 428/31573 Next to addition polymer of ethylenically unsaturated monomer
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane
• CPC Class Codes: Y10T 428/31667 Next to addition polymer from unsaturated monomers, or aldehyde or ketone condensation product
• CPC Class Codes: Y10T 428/31754 Natural source-type polyamide
• CPC Class Codes: Y10T 428/31768 Natural source-type polyamide [e.g., casein, gelatin, etc.]
• CPC Class Codes: Y10T 428/31826 Of natural rubber
• CPC Class Codes: Y10T 428/31913 Monoolefin polymer
• CPC Class Codes: Y10T 428/31928 Ester, halide or nitrile of addition polymer

Abstract

Medical grade adhesive compositions comprising a homogeneous blend of one or more pressure sensitive adhesive materials and one or more natural or synthetic polymers capable of developing elastomeric properties when hydrated such as gluten and long chain polymers of methyl vinyl ether/maleic acid are disclosed. The compositions may also include one or more water soluble hydrocolloid gums and may additionally contain one or more water swellable cohesive strengthening agents.

Claims

1. An adhesive composition suitable for medical purposes comprising a substantially homogeneous mixture on a percent weight basis of from about 30% to about 70% of a pressure sensitive viscous adhesive material and an optional thermoplastic elastomer said pressure sensitive adhesive material selected from the group consisting of natural rubber, silicone rubber, acrylonitrile rubber, polyurethane rubber, and polyisobutylenes and said optional thermoplastic elastomer selected from the group consisting of medium molecular weight polyisobutylene, butyl rubber, and styrene copolymers and from about 3% to about 60% by weight of one or more natural or synthetic polymers capable of developing elastomeric properties when hydrated selected from the group consisting of gluten and long chain polymers of methyl vinyl ether/maleic acid.

2. An adhesive composition of claim 1 wherein said long chain polymer is selected from the group consisting of poly(methyl vinyl ether/maleic acid), poly(methyl vinyl ether/maleic anhydride), and calcium, sodium poly(methyl vinyl ether/maleic acid).

3. An adhesive composition of claim 2 wherein said pressure sensitive viscous adhesive material is low molecular weight polyisobutylene and said polyisobutylene is present at from about 40% to about 50% by weight of said composition.

4. The adhesive composition of claim 3 consisting essentially of on a weight percent basis of about 40% polyisobutylene and about 60% calcium, sodium poly(methyl vinyl ether/maleic acid).

5. An adhesive composition suitable for medical purposes comprising a substantially homogeneous mixture on a percent weight basis of from about 30% to about 70% of a pressure sensitive viscous adhesive material and an optional thermoplastic elastomer said pressure sensitive viscous adhesive material selected from the group consisting of natural rubber, silicone rubber, acrylonitrile rubber, polyurethane rubber, and polyisobutylenes and said optional thermoplastic elastomer selected from the group consisting of medium molecular weight polyisobutylenes, butyl rubber, and styrene copolymers;

from about 3% to about 60% by weight of one or more natural or synthetic polymers capable of developing elastomeric properties when hydrated selected from the group consisting of gluten and long chain polymers of methyl vinyl ether/maleic acid;

up to about 50% by weight of one or more water soluble hydrocolloids selected from the group consisting of sodium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, gum karaya, and mixtures thereof; and

up to about 30% by weight of one or more water swellable cohesive strengthening agents selected from the group consisting of water insoluble cross-linked sodium carboxymethylcellulose, water insoluble starch-acrylonitrile graft polymer, and water insoluble cross-linked dextran provided that the water soluble hydrocolloids and water insoluble cohesive strengthening agents together are no more than about 60% by weight of said adhesive composition.

6. An adhesive composition of claim 5 wherein said long chain polymer is selected from the group consisting of poly(methyl vinyl ether/maleic acid), poly(methyl vinyl ether/maleic anhydride), and calcium, sodium poly(methyl vinyl ether/maleic acid).

7. An adhesive composition of claim 6 wherein said pressure sensitive viscous adhesive material is low molecular weight polyisobutylene.

8. An adhesive composition suitable for medical purposes comprising a substantially homogeneous mixture on a percent weight basis of from about 40% to about 50% of a pressure sensitive adhesive component comprising low molecular weight polyisobutylene and an optional thermoplstic elastomer selected from the group consisting of medium molecular weight polyisobutylene, butyl rubber, and styrene-isoprene-styrene copolymers;

from about 10% to about 35% of a polymer selected from the group consisting of poly(methyl vinyl ether/maleic acid), poly(methyl vinyl ether/maleic anhydride), and calcium, sodium poly(methyl vinyl ether/maleic acid);

from about 15% to about 40% of one or more water soluble hydrocolloids selected from the group consisting of sodium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, gum karaya, and mixtures thereof; and

up to about 30% of one or more water swellable cohesive strengthening agents selected from the group consisting of water insoluble cross-linked sodium carboxymethylcellulose, water insoluble starch-acrylonitrile graft copolymer, water insoluble cross-linked dextran, and mixtures thereof provided that the water soluble hydrocolloids and water swellable cohesive strengthening agents together are no more than about 55% by weight of said composition.

9. An adhesive composition of claim 8 wherein said water soluble hydrocolloids are selected from the group consisting of guar gum, sodium carboxymethylcellulose, and mixtures thereof and said cohesive strengthening agent if present is cross-linked sodium carboxymethylcellulose.

10. The adhesive composition of claim 9 consisting essentially of on a percent weight basis of about 40% low molecular weight polyisobutylene, about 25% guar gum, about 10% sodium carboxymethylcellulose, about 15% cross-linked sodium carboxymethylcellulose, and about 10% calcium, sodium poly(methyl vinyl ether/maleic acid).

11. The adhesive composition of claim 9 consisting essentially of on a weight percent basis of about 40% low molecular weight polyisobutylene, about 25% guar gum, about 10% sodium carboxymethylcellulose, about 15% cross-linked sodium carboxymethylcellulose, and about 10% poly(methyl vinyl ether/maleic acid).

12. The adhesive composition of claim 9 consisting essentially of on a percent weight basis of about 40% low molecular weight polyisobutylene, about 30% sodium carboxymethylcellulose, and about 30% calcium, sodium poly(methyl vinyl ether/maleic acid).

13. The adhesive composition of claim 9 consisting essentially of on a weight percent basis of about 40% low molecular weight polyisobutylene, about 30% guar gum, and about 30% calcium, sodium poly(methyl vinyl ether/maleic acid).

14. The adhesive composition of claim 9 consisting essentially of on a weight percent basis of about 40% low molecular weight polyisobutylene, about 17.2% sodium carboxymethylcellulose, about 25.6% cross-linked sodium carboxymethylcellulose, and about 17.2% calcium, sodium poly(methyl vinyl ether/maleic acid).

15. A skin barrier comprising an adhesive layer having a thin continuous or discontinuous polymeric film laminated to one surface of the adhesive, said adhesive comprising a substantially homogeneous mixture on a percent weight basis of from about 30% to about 70% of a pressure sensitive viscous adhesive material and an optional thermoplastic elastomer said pressure sensitive adhesive material selected from the group consisting of natural rubber, silicone rubber, acrylonitrile rubber, polyurethane rubber, and polyisobutylenes and said optional thermoplastic elastomer selected from the group consisting of medium molecular weight polyisobutylenes, butyl rubber, and styrene copolymers and from about 3% to 60% by weight of one or more natural or synthetic polymers capable of developing elastomeric properties when hydrated selected from the group consisting of gluten and long chain polymers of methyl vinyl ether/maleic acid.

16. A skin barrier of claim 15 wherein said long chain polymer is selected from the group consisting of poly(methyl vinyl ether/maleic acid), poly(methyl vinyl ether/maleic anhydride), and calcium, sodium poly(methyl vinyl ether/maleic acid).

17. A skin barrier of claim 16 wherein said pressure sensitive viscous adhesive material is low molecular weight polyisobutylene and said polyisobutylene is present at from about 40% to about 50% by weight of said composition.

18. A skin barrier of claim 17 wherein said adhesive layer consists essentially of on a weight percent basis of about 40% polyisobutylene and about 60% calcium, sodium poly(methyl vinyl ether/maleic acid).

19. A skin barrier of claim 15 wherein said polymeric film is polyethylene.

20. A skin barrier comprising an adhesive layer having a thin continuous or discontinuous polymeric film laminated on one surface of the adhesive, said adhesive comprising a substantially homogeneous mixture on a percent weight basis of from about 30% to about 70% of a pressure sensitive viscous adhesive material and an optional thermoplastic elastomer said pressure sensitive adhesive material selected from the group consisting of natural rubber, silicone rubber, acrylonitrile rubber, polyurethane rubber, and polyisobutylenes and said optional thermoplastic elastomer selected from the group consisting of medium molecular weight polyisobutylenes, butyl rubber, and styrene compolymers;

from about 3% to about 60% by weight of one or more natural or synthetic polymers capable of developing elastomeric properties when hydrated selected from the group consisting of gluten and long chain polymers of methyl vinyl ether/maleic acid;

up to about 50% by weight of one or more water soluble hydrocolloids selected from the group consisting of sodium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, gum karaya, and mixtures thereof; and

up to about 30% by weight of one or more water swellable cohesive strengthening agents selected from the group consisting of water insoluble cross-linked sodium carboxymethylcellulose, water insouble starch-acrylonitrile graft copolymer, and water insoluble cross-linked dextran provided that the water soluble hydrocolloids and water insoluble cohesive strengthening agents together are no more than about 60% by weight of said adhesive composition.

21. A skin barrier of claim 20 wherein said long chain polymer is selected from the group consisting of poly(methyl vinyl ether/maleic acid), poly(methyl vinyl ether/maleic anhydride), and calcium, sodium poly(methyl vinyl ether/maleic acid).

22. A skin barrier of claim 21 wherein said pressure sensitive viscous adhesive material is low molecular weight polyisobutylene.

23. A skin barrier of claim 20 wherein said polymeric film is polyethylene.

24. A skin barrier comprising an adhesive layer having a thin continuous or discontinuous olymeric film laminated to one surface of the adhesive, said adhesive comprising a substantially homogeneous mixture on a percent weight basis of from about 40% to about 50% of a pressure sensitive adhesive component comprising low molecular weight polyisobutylene and an optional thermoplastic elastomer selected from the group consisting of medium molecular weight polyisobutylene, butyl rubber, and styrene-isoprenestyrene copolymers;

from about 10% to about 35% of a polymer selected from the group consisting of poly(methyl vinyl ether/maleic acid), poly(methyl vinyl ether/maleic anhydride), and calcium, sodium poly(methyl vinyl ether/maleic acid);

from about 15% to about 40% of one or more water soluble hydrocolloids selected from the group consisting of sodium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, gum karaya, and mixtures thereof; and

up to about 30% of one or more water swellable cohesive strengthening agents selected from the group consisting of water insoluble cross-linked sodium carboxymethylcellulose, water insoluble startch-acrylonitrile graft copolymer, water insoluble cross-linked dextran, and mixtures thereof provided that the water soluble hydrocolloids and water swellable cohesive strengthening agents together are no more than about 55% by weight of said composition.

25. A skin barrier of claim 24 wherein said water soluble hydrocolloids are selected from the group consisting of guar gum, sodium carboxymethylcellulose, and mixtures thereof and said cohesive strengthening agent if present is cross-linked sodium carboxymethylcellulose.

26. A skin barrier of claim 25 wherein said adhesive layer consists essentially of on a percent weight basis of about 40% low molecular weight polyisobutylene, about 25% guar gum, about 10% sodium carboxymethylcellulose, about 15% cross-linked sodium carboxymethylcellulose, and about 10% calcium, sodium poly(methyl vinyl ether/maleic acid).

27. A skin barrier of claim 25 wherein said adhesive layer consists essentially of on a percent weight basis of about 40% low molecular weight polyisobutylene, about 25% guar gum, about 10% sodium carboxymethylcellulose, about 15% cross-linked sodium carboxymethylcellulose, and about 10% poly(methyl vinyl ether/maleic acid).

28. A skin barrier of claim 25 wherein said adhesive layer consists essentially of on a percent weight basis of about 40% low molecular weight polyisobutylene, about 30% sodium carboxymethylcellulose, and about 30% calcium, sodium poly(methyl vinyl ether/maleic acid).

29. A skin barrier of claim 25 wherein said adhesive layer consists essentially of on a weight percent basis of about 40% low molecular weight polyisobutylene, about 30% guar gum, and about 30% calcium, sodium poly(methyl vinyl ether/maleic acid).

30. A skin barrier of claim 25 wherein said adhesive layer consists essentially of on a weight percent basis of about 40% low molecular weight polyisobutylene, about 17.2% sodium carboxymethylcellulose, about 25.6% cross-linked sodium carboxymethylcellulose, and about 17.2% calcium, sodium poly(methyl vinyl ether/maleic acid).

31. A skin barrier of claim 24 wherein said polymeric film is polyethylene.