Iodothyronine immunogens and antibodies
First Claim
Patent Images
1. An iodothyronine immunogen conjugate of the formula:
- ##STR6## wherein Carrier is an immunogenic carrier material, R'"'"' is a bond or a linking group, n is an integer from 2 through 12, p is on the average from 1 through about 50, R is hydrogen or alkyl containing 1-6 carbon atoms, and β
1 and β
2 are, independently, hydrogen or iodine.
1 Assignment
0 Petitions
Accused Products
Abstract
Immunogen conjugates comprising N-aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, coupled to an immunogenic carrier material, and antibodies raised against such immunogen conjugates.
162 Citations
23 Claims
-
1. An iodothyronine immunogen conjugate of the formula:
- ##STR6## wherein Carrier is an immunogenic carrier material, R'"'"' is a bond or a linking group, n is an integer from 2 through 12, p is on the average from 1 through about 50, R is hydrogen or alkyl containing 1-6 carbon atoms, and β
1 and β
2 are, independently, hydrogen or iodine. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 17, 18, 19, 20)
- ##STR6## wherein Carrier is an immunogenic carrier material, R'"'"' is a bond or a linking group, n is an integer from 2 through 12, p is on the average from 1 through about 50, R is hydrogen or alkyl containing 1-6 carbon atoms, and β
-
9. An iodothyronine immunogen conjugate of the formula:
- ##STR8## wherein Carrier (CO)--represents an immunogenic protein or polypeptide carrier material bound through a carboxyl group, n is an integer from 2 through 12, p is on the average from 1 through the number of available carboxyl groups on said carrier material, R is hydrogen or alkyl containing 1-6 carbon atoms, and β
1 and β
2 are, indpendently, hydrogen or iodine. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 21, 22, 23)
- ##STR8## wherein Carrier (CO)--represents an immunogenic protein or polypeptide carrier material bound through a carboxyl group, n is an integer from 2 through 12, p is on the average from 1 through the number of available carboxyl groups on said carrier material, R is hydrogen or alkyl containing 1-6 carbon atoms, and β
Specification