Sleep-aid composition containing an analgesic and diphenhydramine dihydrogencitrate, and method of use
First Claim
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1. An analgesic and sleep-aid composition in unit dosage form containing an analgesic component comprising aspirin, acetaminophen or a combination of the two;
- said composition also containing a pharmacologically effective amount of diphenhydramine dihydrogencitrate, said aspirin, acetaminophen or combination of the two being present in analgesically effective amounts;
said analgesic component being present in said unit dosage form in the amount of from about 80 mg. to about 1000 mg.; and
said diphenhydramine dihydrogencitrate being present in said unit dosage form in the range of from about 19 mg. to about 77 mg.
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Abstract
An analgesic and sleep-aid composition containing an analgesic (e.g. aspirin, APAP or combinations thereof) and diphenhydramine dihydrogencitrate. Discloses several dosage forms including a two layer tablet in which aspirin is contained in one layer and APAP contained in the other layer; the preferred form being such that the diphenhydramine dihydrogencitrate is contained in the APAP layer.
28 Citations
19 Claims
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1. An analgesic and sleep-aid composition in unit dosage form containing an analgesic component comprising aspirin, acetaminophen or a combination of the two;
- said composition also containing a pharmacologically effective amount of diphenhydramine dihydrogencitrate, said aspirin, acetaminophen or combination of the two being present in analgesically effective amounts;
said analgesic component being present in said unit dosage form in the amount of from about 80 mg. to about 1000 mg.; and
said diphenhydramine dihydrogencitrate being present in said unit dosage form in the range of from about 19 mg. to about 77 mg. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 14)
- said composition also containing a pharmacologically effective amount of diphenhydramine dihydrogencitrate, said aspirin, acetaminophen or combination of the two being present in analgesically effective amounts;
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9. A two layered analgesic and sleep-aid tablet comprising an aspirin layer and an acetaminophen layer, said tablet containing a pharmacologically effective amount of diphenhydramine dihydrogencitrate;
- the combination of aspirin and acetaminophen in said tablet amounting to from about 80 mg. to about 1000 mg. and the weight ratio of aspirin to acetaminophen being in the range of from about 0.2 to about 5;
said diphenhydramine dihydrogencitrate being present in said tablet in the amount of from about 19 mg. to about 77 mg. - View Dependent Claims (10, 11, 12, 13)
- the combination of aspirin and acetaminophen in said tablet amounting to from about 80 mg. to about 1000 mg. and the weight ratio of aspirin to acetaminophen being in the range of from about 0.2 to about 5;
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15. A process for preparing a two layered analgesic and sleep-aid tablet which comprises:
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(a) forming a first granulation comprising aspirin; (b) charging said aspirin granulation into a tablet die to form the first layer of tablet material; (c) forming a second granulation comprising acetaminophen and diphenhydramine dihydrogencitrate; (d) charging said second granulation into said tablet die to form a second layer of tablet material; and (e) compressing said first and second layers to form said two layered tablet; (f) the quantity of analgesic added being such that each tablet contains from about 80 mg. to about 1000 mg. of the combination of aspirin and acetaminophen and the quantity of diphenhydramine dihydrogencitrate added is such that each tablet contains from about 19 mg. to about 77 mg. of diphenhydramine dihydrogencitrate. - View Dependent Claims (16, 17, 18, 19)
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Specification