Apparatus and method for separating fluid into components thereof
First Claim
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1. Apparatus for use in the centrifugal separation of blood into at least a first blood component and a second blood component, comprising, in combination:
- a. a flexible blood processing bag having an inlet port and an outlet port;
b. blood-compatible tubing providing fluid communication between the inlet port of said flexible blood processing bag and connection means for connecting said blood compatible tubing to a source of blood to be separated;
c. a receiver-container for receiving first blood component separated in said flexible blood processing bag;
d. blood-compatible tubing providing a fluid communication path between the outlet port of said flexible blood processing bag and said receiver container; and
e. valve means for preventing fluid communication between said flexible blood processing bag and said receiver container in response to the difference between the specific gravities of separated first and second blood components.
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Abstract
An improved method and apparatus are disclosed for sealing the outlet port of a flexible blood-processing bag after a separated first blood component has been expressed therefrom. The improvements relate to the use of a valve contained within the flexible blood-processing bag and responsive to the difference in specific gravities between first blood component and second blood component. For example, the valve may comprise a stopper ball having a specific gravity which allows it to float at the interface between first and second blood component.
77 Citations
25 Claims
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1. Apparatus for use in the centrifugal separation of blood into at least a first blood component and a second blood component, comprising, in combination:
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a. a flexible blood processing bag having an inlet port and an outlet port; b. blood-compatible tubing providing fluid communication between the inlet port of said flexible blood processing bag and connection means for connecting said blood compatible tubing to a source of blood to be separated; c. a receiver-container for receiving first blood component separated in said flexible blood processing bag; d. blood-compatible tubing providing a fluid communication path between the outlet port of said flexible blood processing bag and said receiver container; and e. valve means for preventing fluid communication between said flexible blood processing bag and said receiver container in response to the difference between the specific gravities of separated first and second blood components. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. Apparatus comprising:
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a. a flexible blood processing bag having an output port and adapted to contain anticoagulated whole blood; b. a receiving container having an input port and adapted to receive a component of said whole blood; c. tubing means providing fluid communication between the output port of the bag and the input port of the receiving container; and d. valve means for terminating flow of fluid component out the output port of the bag in response to the specific gravity of said component. - View Dependent Claims (12, 13, 14, 15, 16)
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17. In a process wherein blood is separated into a first blood component and second blood component in a blood processing chamber and first blood component is thereafter caused to flow through an outlet port of said chamber through a conduit and into a receiver container:
The improvement of stopping flow to the container by a valve means having a stopper with a specific gravity which allows it to float on the interface between first and second blood components within said chamber. - View Dependent Claims (18, 19, 20, 21)
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22. A method comprising:
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(a) rotating a volume of whole blood contained in a first container in a centrifuge at a speed sufficient to separate said whole blood into at least two components, a less dense and more dense component; (b) forcing one of the components to flow from said bag to a second container while said volume is being rotated; (c) preventing the flow in step (b) until substantial separation occurs in step (a) and; (d) causing said flow to stop by control means in the centrifuge when substantially all of the component in step (b) has flowed from the bag. - View Dependent Claims (23, 24, 25)
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Specification