Method for treating blood plasma employing a hollow fiber membrane
First Claim
1. A method for treating the blood plasma to selectively reduce the amount of a disease factor therein comprising fractionating the plasma with a hollow fiber membrane comprising a skin layer on at least one surface of said membrane and a porous layer inside said membrane with average pore size of micropores of said skin layer in the range of 50 to 450 A, that of micropores of the porous layer ranging from 500 to 15,000 A, void volume of said membrane at a level of 50 to 85% and water permeability at a level of 80 ml/m2.hr.mmHg or higher, such that the amount of the disease factor in one of the fractions produced is decreased.
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Abstract
This invention provides a method for treating blood plasma wherein a hollow fiber membrane which comprises at least a skin layer on one surface of the membrane and also a porous layer inside the membrane is employed. The skin layer of the membrane has micropores with average pore size of 50 to 450 A, and the membrane shows a water permeability of 80 ml/m2.hr.mmHg or more, and permeabilites for human blood plasma albumin of 85% or more and for human blood plasma immunoglobulin G(IgG) of 80% or more, and a rate of inhibition against human blood plasma immunoglobulin M(IgM) of 40% or more. Use of the above mentioned hollow fiber membrane, which makes it possible to selectively remove immune complex, rheumatoid factors, etc., without decrease in levels of immunological functions, brings excellent effects on therapy of autoimmune diseases.
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Citations
8 Claims
- 1. A method for treating the blood plasma to selectively reduce the amount of a disease factor therein comprising fractionating the plasma with a hollow fiber membrane comprising a skin layer on at least one surface of said membrane and a porous layer inside said membrane with average pore size of micropores of said skin layer in the range of 50 to 450 A, that of micropores of the porous layer ranging from 500 to 15,000 A, void volume of said membrane at a level of 50 to 85% and water permeability at a level of 80 ml/m2.hr.mmHg or higher, such that the amount of the disease factor in one of the fractions produced is decreased.
Specification