Orthopaedic cement from acrylate polymers

• US 4,404,327 A
• Filed: 03/01/1982
• Issued: 09/13/1983
• Est. Priority Date: 10/31/1979
• Status: Expired due to Term

• Current Assignee: Aldo M. Crugnola, Edward J. Ellis
• Original Assignee: Aldo M. Crugnola, Edward J. Ellis
• Inventors: Ellis, Edward J., Crugnola, Aldo M.
• Primary Examiner(s): SECCURO JR, CARMAN J
• Application Number:
  US06/353,597
• Time in Patent Office: 561 Days
• Field of Search: 523/116, 523/115, 433/228, 525/309, 525/228
• US Class Current: 525/228
• CPC Class Codes: A61F 2002/4631 the prosthesis being specially adapted for being cemented
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: C08L 2205/22 Mixtures comprising a continuous polymer matrix in which are dispersed crosslinked particles of another polymer
• CPC Class Codes: C08L 2666/04 Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
• CPC Class Codes: C08L 33/10 Homopolymers or copolymers of methacrylic acid esters
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate

Abstract

An improved orthopaedic cement of the type used to, e.g. position and hold prosthetic devices in place within bone cavities after surgical repair of the bone system. The cement is characterized by markedly increased toughness and resistance to fracture due to the rubbery, or elastomeric, nature of the included polyacrylate resin phase.

Claims

1. An improved orthopaedic cement comprising acrylate matrix polymer together with a powder formed of a second acrylate polymer which second polymer has a solubility parameter within about 0.2 units from the monomer from which said matrix polymer is formed, which has a glass transition temperature below human body temperature (37°

C.) and which, at said human body temperature, is substantially more extensible than said matrix polymer;

said cement, when implanted in the human body, at body temperature being a composite material consisting of relatively rubbery polymer particles embedded in a rigid, glassy matrix of polymethyl methacrylate and having a setting time of about ten to fifteen minutes.

2. The cement of claim 1 wherein said matrix polymer is polymethlymethacrylate and said powder is formed from a polymer having an elongation of at least 90%, and a tensile modulus of at least 200 psi.

3. The cement of claim 1 wherein said matrix polymer is polymethlymethacrylate and said powder is formed from a polymer having an elongation of at least 120%, and a tensile modulus of at least 300 psi.

4. A cement as defined in claim 1 wherein said powder is poly n-butyl methacrylate.

5. A cement as defined in claim 1 wherein said cement withstands a stress of fracture stress of about 20×

10 dynes/cm² and has a modulus of less than about 2×

10¹⁰ dynes/cm².

6. A cement as defined in claim 1 wherein said cement comprises an x-ray opacifying quantity of filler and a modulus of less than about 2×

10¹⁰ dynes/cm².

7. A cement as defined in claim 1 wherein the solubility parameter of polymerizable material from which said matrix is formed and said powder polymer are within about 0.2 units and wherein said cement withstands a fracture stress of about 20 dynes/cm² and has a modulus of less than about 2×

10¹⁰ dynes/cm².

8. An orthopaedic cement as specified in claim 1 wherein:

said relatively rubbery polymer is cross-linked n-butyl methacrylate polymer.

9. An orthopaedic cement as specified in claim 1 wherein:

said relatively rubbery polymer is a co-polymer of n-butyl methacrylate and tris (trimethylsilyl) siloxanylpropyl acrylate.

10. An orthopaedic cement comprising, at human body temperature, a relatively rubbery polymer in a rigid matrix polymer:

said relatively rubbery polymer being poly n-butyl methacrylate which in use condition has an elongation of at least 90%, a tensile modulus of at least 200 psi and a glass transition temperature below said human body temperature (37°

C.);

said rigid matrix polymer being polymethyl methacrylate;

the solubility parameters of said rigid matrix polymer and said relatively rubbery polymer being within about 0.2 units;

and said cement being characterized by withstanding a fracture stress of about 20 dynes/cm², having a modulus of less than about 2×

10¹⁰ dynes/cm²,;

including an X-ray opacifying quantity of filler and having a setting time of ten to fifteen minutes.