Brain electrical activity mapping

• US 4,407,299 A
• Filed: 05/15/1981
• Issued: 10/04/1983
• Est. Priority Date: 05/15/1981
• Status: Expired due to Fees

• Current Assignee: Children's Medical Center Corporation
• Original Assignee: Children's Medical Center Corporation
• Inventors: Culver, Norman D.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Sykes, Angela D.
• Application Number:
  US06/264,031
• Time in Patent Office: 872 Days
• Field of Search: 128/731-733, 128/905
• US Class Current: 600/544
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

Information on brain electrical activity is derived from electrical-activity transducers spaced apart over the skull, the information is processed into a time sequence of matrices having elements representing the responses of the transducers, a succession of overlapping running-average matrices is generated each corresponding to an average of a plurality of the matrices in the time sequence, and the running-average matrices are displayed as a sequence of topographic maps. Expanded display matrices are generated from the data matrices by adding new matrix elements using three-point linear interpolation based on pre-stored coefficients corresponding to the location of each new matrix element with respect to the three closest transducer locations.

Claims

1. Apparatus for generating a topographic display of information on the electrical activity of the brain, said apparatus comprising

a plurality of electrical-activity transducers adapted to be placed at spaced apart locations on the skull of a patient,

processing means connected to be responsive to said transducers to generate a time sequence of response matrices, the elements of each said response matrix representing the instantaneous amplitudes of responses of said transducers at various locations on the skull,

said processing means including means to generate from said time sequence of response matrices a succession of running-average matrices each corresponding to an average of a plurality of successive response matrices in said sequence, at least two of said running-average matrices corresponding respectively to two averages which include in common at least one of said response matrices,

display means connected to be responsive to said processing means, for displaying said running-average matrices as a time sequence of topographic maps of the skull, the elements of said running-average matrices defining discrete points of said maps.

2. Apparatus for generating a topographic display of information on the electrical activity of the brain, said apparatus comprising

a plurality of electrical-activity transducers adapted to be placed at spaced apart locations on the skull of a patient,

sampling means connected to be responsive to said transducers, for sampling responses measured at said transducers and storing the response samples as a series of data matrices, one matrix for each sample taken,

processing means connected to be responsive to said dampling means, for processing said data matrices to generate one or more processed matrices,

interpolation means connected to be responsive to said processing means, for generating one or more expanded matrices by expanding the number of elements in said processed matrices to provide elements corresponding to skull locations intermediate said transducer locations, said interpolation means including

means for storing three predetermined interpolation coefficients for each new matrix element to be generated by interpolation, said coefficients corresponding to the skull location of said new matrix element with respect to the three closest transducer locations,

means for generating each said new matrix element by multiplying said coefficients by the existing elements of said processed matrix corresponding to the three closest transducer locations and summing the three products,

display means for displaying said expanded matrices as topographic maps of the skull, said matrix elements forming discrete points of said maps.

3. A method for generating a topographic display of information on the electrical activity of the brain, said method comprising the steps of

placing a plurality of electrical-activity transducers at spaced apart locations on the skull of a patient,

processing responses at said transducers to generate a time sequence of response matrices, the elements of each said response matrix representing the instantaneous amplitudes of said responses at various locations on the skull,

said processing step including generating from said time sequence of response matrices a succession of running-average matrices each corresponding to an average of a plurality of successive response matrices in said sequence, at least two of said running-average matrices corresponding respectively to averages which include in common at least one of said response matrices,

displaying said running-average matrices as a time sequence of topographic maps of the skull, the elements of said running-average matrices defining discrete points of said maps.

4. A method for generating a topographic display of information on the electrical activity of the brain, said method comprising the steps of

placing a plurality of electrical-activity transducers at spaced apart locations on the skull of a patient,

sampling responses measured at said transducers and storing the response samples as a series of data matrices, one matrix for each sample taken,

processing said data matrices to generate one or more processed matrices,

generating one or more expanded matrices by expanding the number of elements in said processed matrices to provide elements corresponding to skull locations intermediate said transducer locations, said generating step including

storing three predetermined interpolation coefficients for each new matrix element to be generated by interpolation, said coefficients corresponding to the skull location of said new matrix element with respect to the three closest transducer locations,

generating each said new matrix element by multiplying said coefficients by the existing elements of said processed matrix corresponding to the three closest transducer locations and summing the three products,

displaying said expanded matrices as topographic maps of the skull, said matrix elements forming discrete points of said maps.