Glass composition

• US 4,407,786 A
• Filed: 04/09/1981
• Issued: 10/04/1983
• Est. Priority Date: 12/21/1978
• Status: Expired due to Fees

• Current Assignee: STC PLC (f/k/a Standard Telephones and Cables)
• Original Assignee: International Standard Electric Corporation (ITT, Inc.)
• Inventors: Drake, Cyril F., Tripp, Mary
• Primary Examiner(s): McCarthy, Helen M.
• Application Number:
  US06/252,662
• Time in Patent Office: 908 Days
• Field of Search: 501/45, 501/48, 501/33, 501/35, 501/24, 424/14, 424/140
• US Class Current: 424/426
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/08 containing solids as carriers or diluents
• CPC Class Codes: A01N 59/20 Copper
• CPC Class Codes: A01N 59/26 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: C03C 12/00 Powdered glass C03C8/02 takes precedence; Bead compositions
• CPC Class Codes: C03C 3/16 containing phosphorus
• CPC Class Codes: C03C 3/17 containing aluminium or beryllium
• CPC Class Codes: C03C 4/0035 for soluble glass for controlled release of a compound incorporated in said glass
• CPC Class Codes: C05B 17/00 Other phosphatic fertilisers, e.g. soft rock phosphates, bone meal
• CPC Class Codes: C05D 9/02 containing trace elements

Abstract

A copper phosphate water soluble glass composition. The composition of the glass may be adjusted so as to release copper at a uniform preselected rate and to produce a desired pH in the resultant solution. In one application of the glass copper may be supplied to an animal from an implant formed from a cupric oxide/phosphorus pentoxide glass which also incorporates one or more glass modifying oxides such as alkali metal oxides and alumina, to control the glass solubility. Suitable glasses comprise 5-55 mole % cupric oxide + alkali metal oxides. 45-75 mole % phosphorus pentoxide, and not more than 15 mole % alumina, where the copper oxide concentration is not less than 5 mole %.

Claims

1. A subcutaneous implant for supplying copper to the bloodstream or body fluid of an animal, the implant comprising a glass body completely soluble in the body fluid of the animal for releasing copper into solution at a predetermined uniform rate when implanted beneath the skin of the animal and leaving no residue when completely dissolved, wherein the glass body consists of cupric oxide as the source of copper, at least one alkali metal oxide as a first glass-modifying oxide, 45 to 75 mole percent phosphorous pentoxide as a glass-forming oxide present in the glass body in a predetermined concentration chosen to provide a solution with the body fluids of the animal having a pH physiologically compatible with the animal, and sufficient alumina as a second glass-modifying oxide to reduce the solubility of the glass body to the predetermined uniform rate suitable for supplementing the copper ingested by the animal from other sources to provide the total amount of copper necessary for nutrition without toxic side effects, and wherein the cupric oxide concentration is not less than 5 mole percent, said cupric oxide and alkali metal oxide concentration together is 5 to 55 mole percent, wherein the alkali metal oxide is an oxide of sodium or potassium or a combination thereof, and the alumina concentration is not more than 4 mole percent.

2. The implant recited in claim 1 wherein the glass body is at least one spherical, rod-shaped or pellet-shaped form suitable for subcutaneous injection into the animal with a hypodermic needle.

3. A method of supplying copper to the bloodstream of an animal with a subcutaneous implant that releases copper as it dissolves in the body fluids of the animal and leaves no residue when completely dissolved, the method comprising:

providing the glass body recited in claim 1 or 2, wherein the composition of the glass body provides a solution with the body fluids of the animal having a pH physiologically compatible with the animal and releases copper at a uniform rate that supplements the copper ingested by the animal from other sources to provide the total amount of copper necessary for proper nutrition without toxic side effects; and

implanting said glass body beneath the skin of the animal.