Ophthalmic solutions

• US 4,407,791 A
• Filed: 09/28/1981
• Issued: 10/04/1983
• Est. Priority Date: 09/28/1981
• Status: Expired due to Term

• Current Assignee: Alcon Manufacturing Limited (Alcon Incorporated)
• Original Assignee: Alcon Laboratories Incorporated (Alcon Incorporated)
• Inventors: Stark, Raymond L.
• Primary Examiner(s): Robinson, Douglas W.
• Application Number:
  US06/306,317
• Time in Patent Office: 736 Days
• Field of Search: 424/78, 424/329, 424/80, 564/295
• US Class Current: 424/78.04
• CPC Class Codes: A61K 31/785 Polymers containing nitrogen
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

This invention relates to the quaternary ammonium salt, α-4-[-tris (2-hydroxyethyl) ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride, providing aqueous disinfecting solutions for contact lenses as well as a preservative for ocular solutions including contact lens treating solutions.

Claims

1. A method of imparting antimicrobial activity to an aqueous ophthalmic contact lens solution comprising:

adding to said solution from about 0.00001% to about 3.0% by weight/volume of α

-4-[1-tris(2-hydroxyethyl) ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride as an antimicrobial agent.

2. A method as recited in claim 1 wherein said antimicrobial agent preserves said solution and comprises from about 0.0001% to about 0.005% by weight/volume of said solution.

3. A method as recited in claim 1 wherein said antimicrobial agent comprises from about 0.001% to about 0.01% by weight/volume of said solution and wherein said solution disinfects a contact lens.

4. A method as recited in claim 2 wherein said antimicrobial agent has a molecular weight sufficiently large to substantially preclude adsorption, absorption or physical binding onto a soft contact lens.

5. A method as recited in claim 2 comprising further adding to said ophthalmic solution from about 0.01% to about 0.2% by weight/volume of polyvinylalcohol and from about 0.001% to about 0.005% by weight/volume thimerosal.

6. A method as recited in claim 2 comprising further adding to said ophthalmic solution about 0.01% to about 0.2% by weight/volume of polyvinylpyrrolidone.

7. A method as recited in claim 2 comprising further adding to said ophthalmic solution disodium edetate, sodium chloride and a buffer, said ophthalmic solution having a pH in the range of about 5.0 to about 8.5.

8. A method as recited in claim 4 wherein said antimicrobial agent has a molecular weight in the range from about 1200 to about 3100.

9. A method as recited in claim 3 wherein said antimicrobial agent has a molecular weight sufficiently large to substantially preclude adsorption, absorption or physical binding onto a soft contact lens.

10. A method as recited in claim 3 wherein said ophthalmic solution further comprises about 0.01% to about 0.2% by weight/volume polyvinylpyrrolidone.

11. A method as recited in claim 3 wherein said solution comprises from about 0.01% to about 0.2% by weight/volume of polyvinyl alcohol and from about 0.001% to about 0.005% by weight/volume thimerosal.

12. A method as recited in claim 3 wherein said solution further comprises disodium edetate, sodium chloride, and a buffer, said ophthalmic solution having a pH in the range of about 5.0 to about 8.5.

13. A method as recited in claim 9 wherein said antimicrobial agent has a molecular weight in the range from about 1200 to about 3100.

14. A method of disinfecting a contact lens comprising:

contacting said lens with a solution comprising from about 0.001% to about 0.01% by weight/volume of α

-4-[1-tris(2-hydroxyethyl ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride as an antimicrobial agent.

15. A method as recited in claim 14 wherein said antimicrobial agent has a molecular weight sufficiently large to substantially preclude adsorption, absorption or physical binding onto a soft contact lens.

16. A method as recited in claim 15 wherein said antimicrobial agent has a molecular weight in the range from about 1200 to about 3100.

17. A method as recited in claim 15 further comprising heating said ophthalmic solutions and said contact lens in a temperature range from about 60°

C. to about 100°

C.