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Synthetic peptides having pituitary growth hormone releasing activity

  • US 4,411,890 A
  • Filed: 12/28/1981
  • Issued: 10/25/1983
  • Est. Priority Date: 04/14/1981
  • Status: Expired due to Term
First Claim
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1. A peptide having a formula ##STR72## wherein X1, X2, and X3 are selected from a group consisting of --R, --OR, RC(O)-- wherein R is selected from a group consisting of hydrogen and straight chain and branched chain alkyl groups containing 1-6 carbon atoms;

  • a and b are 0 or 1, provided that a and b are 0 when A1 is a desamino residue;

    A1 and A4 are selected from a group consisting of His, Arg, Lys, α

    -Naphth, β

    -Naphth, IQl, Tyr, Trp, Phe, homologues and analogues thereof, and, with respect to A1, the desamino forms thereof;

    A2 and A5 are selected from a group consisting of D-His, D-Arg, D-Lys, D-α

    -Naphth, D-β

    -Naphth, D-Iql, D-Tyr, D-Trp, D-Phe, and homologues and analogues thereof;

    A3 is selected from a group consisting of Gly, Ala, Val, Leu, Ile, Pro, Ser, Thr, Met, Asp, Glu, Asn, Gln, His, D-Ala, D-Val, D-Leu, D-Ile, D-Pro, D-Ser, D-Thr, D-Met, D-Asp, D-Glu, D-Asn, D-Gln, D-His, and homologues and analogues thereof;

    A6 is selected from a group consisting of amino acids of the L- and D-configuration, homologues and analogues thereof, and the descarboxy forms thereof; and

    Y is selected from a group consisting of C-terminal and descarboxy alpha-carbon substitutions;

    and the pharmaceutically acceptable salts thereof.

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