Airless artificial kidney assembly

• US 4,412,916 A
• Filed: 06/24/1981
• Issued: 11/01/1983
• Est. Priority Date: 06/24/1981
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: Cordis Dow Corp. (Baxter International Inc.)
• Inventors: Kell, Michael J.
• Primary Examiner(s): Sadowski, David R.
• Application Number:
  US06/276,751
• Time in Patent Office: 860 Days
• Field of Search: 210/87, 210/90, 210/94, 210/120, 210/188, 210/259, 210/260, 210/262, 210/295, 210/296, 210/300, 210/305-310, 210/321, 210/323, 210/335, 210/433, 210/436, 210/455 , 210/456, 210/472, 210/927, 128/675, 128/748, 128/DIG. 3, 128/214, 73/38, 73/714, 73/706, 73/715, 55/59, 55/318, 55/421
• US Class Current: 210/90
• CPC Class Codes: A61M 1/3627 Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 1/3641 Pressure isolators
• CPC Class Codes: A61M 1/3676 by interposing a liquid layer between blood and air
• CPC Class Codes: B01D 19/0031 by filtration

Abstract

The invention provides an artificial kidney extracorporeal circuit assembly including an artificial kidney having detachably attached multifunctional subassembly means for automatically venting gas bubbles from liquid flowing therethrough, for continuously sensing the liquid pressure of and for filtering said liquid, together with blood tubes for connecting a patient'"'"'s artery to the kidney and the subassembly outlet port to a patient'"'"'s vein.

The subassembly includes means associated with a hydrophobic gas bubble vent which prevent clogging, minimize blood clotting and insure against ambient gas entry through the vent.

Claims

1. An airless artificial kidney assembly comprising

(1) an artificial kidney having inlet and outlet ports,

(2) a liquid-tight subassembly having a filter, microporous vent means for venting to atmosphere gas bubbles separated from liquid in said subassembly and preventing gas entry through said vent means into said subassembly, pressure measuring means for continuously monitoring the pressure of liquid in said subassembly, a housing for blood having an upper region and an outlet connector communicating with said housing for discharging blood therefrom,

(3) a first tube secured at one end to said kidney inlet port and terminating at its opposite end in a connector for connecting said first tube with a patient,

(4) a second tube secured at one end to said outlet connector of said subassembly and terminating at its opposite end in a connector for connecting said second tube with a patient,

(5) said kidney outlet port opening into said housing for discharging blood thereinto,

said filter being arranged for filtering blood flowing from said kidney outlet port to said outlet connector, said vent means comprising an upwardly opening microporous hydrophobic vent in communication with said upper region of said housing for receiving and discharging air bubbles therefrom, and means containing an aqueous solution overlying said vent for preventing downward flow of air through said vent into said housing.

2. An airless artificial kidney assembly as claimed in claim 1, said vent means comprising a horizontal disc having interior and exterior surfaces, said means containing an aqueous solution comprising a cover secured to said housing and spaced from and overlying the exterior surface of said vent to provide a container for said aqueous solution, said cover being apertured for passage of water therethrough.

3. An airless artificial kidney assembly as claimed in claim 2, wherein a second cover is secured to said housing and spaced from and overlying the first named cover, said second cover having an aperture for passage of water to enable filling of said container from the exterior of said assembly.

4. An airless artificial kidney assembly as claimed in claim 1 wherein said kidney is a hollow fiber artificial kidney, said subassembly, filter, vent and pressure measuring means are contained in a single housing detachable from said kidney and said second tube and wherein said vent is located adjacent the upper end of said housing, said pressure measuring means is located adjacent the lower end of said housing and said filter is located between said vent and said pressure measuring-means.

5. A multi-functional, liquid-tight subassembly for attachment to an artificial kidney for filtering flowing liquid, automatically separating gas bubbles from liquid therein, and continuously monitoring pressure of liquid therein which comprises

(1) a hollow elongated housing having upper and lower ends,

(2) liquid inlet means adjacent one end of said housing,

(3) liquid outlet means adjacent the opposite end of said housing,

(4) a microporous vent sealingly enclosing the upper end of said housing at a location above said inlet means, said vent having interior and exterior surfaces,

(5) means for effecting a stagnant pool of fluid immediately adjacent the interior surface of said vent comprising diverting means within said housing adjacent to said liquid inlet means for diverting the direction of flow of liquid entering said housing through said liquid inlet means initially directly away from said interior surface of said microporous vent for preventing said flow from sweeping across said interior surface of said microporous vent,

(6) a filter in said housing below said inlet means for filtering fluid flowing in said housing from said inlet means to said outlet means,

(7) pressure sensing means located below said filter in a wall of said housing for continuously sensing pressure changes in the pressure of liquid flowing through said subassembly.

6. A subassembly as claimed in claim 5, wherein said subassembly comprises said filter sealingly attached to the inner wall of said housing at a location below said inlet means to receive liquid diverted by said diverting means.

7. A subassembly as claimed in claim 5 wherein said microporous vent is overlaid with cover means spaced above said vent, said cover means provided with at least one aperture for venting gas through said microporous vent to atmosphere.

8. A subassembly as claimed in claim 5 wherein said microporous vent is overlaid with cover means spaced above said vent, said cover means provided with at least one aperture for venting gas through said microporous vent to atmosphere, and wherein said vent is hydrophobic and overlaid with water in the space between the upper surface of said vent and the lower surface of said cover.

9. A subassembly as claimed in claim 5 wherein said liquid pressure measuring means comprises a compressible concave diaphragm extending into the cavity within said housing and forming the inner wall portion of gas-tight receptacle having means for attaching a tubular connector on the outer wall portion of said receptacle to pressure indicating means located remotely from said liquid pressure measuring means.

10. A subassembly as claimed in claim 5 wherein said housing is provided with at least one injection site located in the wall of said housing which faces outwardly when said subassembly is secured to the outlet part of an artificial kidney.

11. An airless artificial kidney assembly comprising

(1) an artificial kidney having inlet and outlet ports,

(2) a liquid-tight subassembly having a filter, microporous vent means for venting to atmosphere gas bubbles separated from liquid in said subassembly, pressure measuring means for continuously monitoring the pressure of liquid in said subassembly, a housing for blood having an upper region, and an outlet connector communicating with said housing for discharging blood therefrom,

(3) a first tube secured at one end to said kidney inlet port and terminating at its opposite end in a connector for connecting said first tube with a patient,

(4) a second tube secured at one end to said outlet connector of said subassembly and terminating at its opposite end in a connector for connecting said second tube with a patient, said kidney outlet port opening into said housing for discharging blood thereinto,

(5) means for providing a stagnant pool of blood in said upper region of said housing,

(6) said vent means being in communication with said stagnant pool in said upper region for receiving and discharging air bubbles therefrom, said means for providing said stagnant pool comprising baffle means within said housing adjacent to said inlet means for diverting the direction of flow of liquid entering said housing through said inlet means initially directly away from said vent means for preventing said flow from sweeping across said vent means, and said filter being arranged for filtering blood flowing in said housing from said kidney outlet port to said outlet connector.

12. An airless artificial kidney assembly as claimed in claim 11, said vent means comprising a microporous hydrophobic vent in communication with said stagnant pool and opening upwardly at the top of said upper region of said housing, and means for providing an aqueous layer above said vent for preventing gas entry through said vent into said housing.

13. An airless artificial kidney assembly as claimed in claim 12, said vent comprising a horizontal disc having an interior surface in communication with said stagnant pool and having an exterior surface, said means for providing said aqueous layer comprising a cover secured to said housing and spaced from and overlying the exterior surface of said vent to provide a container for said aqueous solution, said cover being apertured for passage of water therethrough.

14. An airless artificial kidney assembly as claimed in claim 13, a second cover secured to said housing and spaced from and overlying the first named cover, said second cover having an aperture for passage of water to enable filling of said container from the exterior of said assembly.