Phosphoramidite compounds and processes
First Claim
Patent Images
1. A compound represented by one of the formulae:
- ##STR4## wherein B is a nucleoside or deoxynucleoside base;
A is H, OH or OR2 in which R2 is a blocking group;
R is a blocking group;
R1 is a hydrocarbyl radical containing up to about 10 carbon atoms; and
X is NR2 R3, wherein R2 and R3 taken separately each represent alkyl, aryl, aralkyl, cycloalkyl and cycloalkylalkyl containing up to 10 carbon atoms;
R2 and R3 when taken together form an alkylene chain containing up to 5 carbon atoms in the principal chain and a total of up to 10 carbon atoms with both terminal valence bonds of said chain being attached to the nitrogen atom to which R2 and R3 are attached; and
R2 and R3 when taken together with the nitrogen atom to which they are attached form a saturated nitrogen heterocycle including at least one additional heteroatom from the group consisting of nitrogen, oxygen and sulfur.
1 Assignment
0 Petitions
Accused Products
Abstract
A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.
-
Citations
20 Claims
-
1. A compound represented by one of the formulae:
- ##STR4## wherein B is a nucleoside or deoxynucleoside base;
A is H, OH or OR2 in which R2 is a blocking group;
R is a blocking group;
R1 is a hydrocarbyl radical containing up to about 10 carbon atoms; and
X is NR2 R3, wherein R2 and R3 taken separately each represent alkyl, aryl, aralkyl, cycloalkyl and cycloalkylalkyl containing up to 10 carbon atoms;
R2 and R3 when taken together form an alkylene chain containing up to 5 carbon atoms in the principal chain and a total of up to 10 carbon atoms with both terminal valence bonds of said chain being attached to the nitrogen atom to which R2 and R3 are attached; and
R2 and R3 when taken together with the nitrogen atom to which they are attached form a saturated nitrogen heterocycle including at least one additional heteroatom from the group consisting of nitrogen, oxygen and sulfur. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 17, 18)
- ##STR4## wherein B is a nucleoside or deoxynucleoside base;
-
2. A compound represented by the formula:
- ##STR5## wherein B is a nucleoside or deoxynucleoside base;
A is H, OH or OR2 in which R2 is a blocking group;
R is a blocking group;
R1 is a hydrocarbyl radical containing up to about 10 carbon atoms; and
X is NR2 R3, wherein R2 and R3 taken separately each represent alkyl, aryl, aralkyl, cycloalkyl and cycloalkylalkyl containing up to 10 carbon atoms;
R2 and R3 when taken together form an alkylene chain containing up to 5 carbon atoms in the principal chain and a total of up to 10 carbon atoms with both terminal valence bonds of said chain being attached to the nitrogen atom to which R2 and R3 are attached; and
R2 and R3 when taken together with the nitrogen atom to which they are attached form a saturated nitrogen heterocycle including at least one additional heteroatom from the group consisting of nitrogen, oxygen and sulfur. - View Dependent Claims (12, 13, 14, 15, 16, 19, 20)
- ##STR5## wherein B is a nucleoside or deoxynucleoside base;
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
-
Current AssigneeUniversity Patents, Inc.
-
Original AssigneeUniversity Patents, Inc.
-
InventorsCaruthers, Marvin H., Beaucage, Serge L.
-
Primary Examiner(s)Love, Ethel G.
-
Application NumberUS06/248,450Time in Patent Office963 DaysField of Search536/27, 536/28, 536/29US Class Current536/26.5CPC Class CodesC07H 21/00 Compounds containing two or...
