Pheresis apparatus
First Claim
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1. Apparatus comprising:
- (a) a centrifuge;
(b) an enclosed fractionation volume on said centrifuge;
(c) an inlet and outlet port mounted on said centrifuge, the ports being in fluid communication with said fractionation volume;
(d) receptacle means outside said centrifuge for collecting a first fractionated whole blood component from said outlet port;
(e) pump means for (i) first causing whole blood to flow into said inlet port at a predetermined rate and (ii) secondly for causing a first fractionated component of whole blood to be recirculated to the inlet port of said centrifuge to elutriate the remaining contents in the fractionation volume.
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Abstract
This invention relates to an improvement in two-port centrifuge bowls in which component yield is enhanced by utilizing the centrifuge bowl for eluttriation, as well as centrifugation. In a particular embodiment, platelet yield is improved by terminating flow of anticoagulated whole blood from the donor to the bowl and pumping low density fluid, preferably plasma, back into the bowl at a relatively high rate to elutriate centrifugally separated cells in the bowl.
208 Citations
18 Claims
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1. Apparatus comprising:
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(a) a centrifuge; (b) an enclosed fractionation volume on said centrifuge; (c) an inlet and outlet port mounted on said centrifuge, the ports being in fluid communication with said fractionation volume; (d) receptacle means outside said centrifuge for collecting a first fractionated whole blood component from said outlet port; (e) pump means for (i) first causing whole blood to flow into said inlet port at a predetermined rate and (ii) secondly for causing a first fractionated component of whole blood to be recirculated to the inlet port of said centrifuge to elutriate the remaining contents in the fractionation volume. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. Apparatus for fractionating whole blood into components thereof comprising:
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(a) a centrifuge; (b) an enclosed fractionation volume on said centrifuge; (c) an inlet and outlet port mounted on said centrifuge, the ports being in fluid communication with said fractionation volume; (d) first pump means for causing whole blood to flow into said inlet port at a predetermined rate; (e) receptacle means outside said centrifuge for collecting fractionated whole blood component from said outlet port; (f) second pump means for causing a first fractionated component of said whole blood to be recirculated to the inlet port of said centrifuge to elutriate the remaining contents in the fractionation volume, thereby achieving enhanced separation of component within said centrifuge. - View Dependent Claims (11, 12, 13, 14, 15)
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16. The method of increasing component yield from donated whole blood in a two-port centrifugation bowl wherein:
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(i) lower density component is separated in the bowl from higher density component in the bowl and the lower density component is displaced to a separate container; and (ii) the lower density component is returned to the bowl to elutriate the higher density components remaining in the bowl; and (iii) component with density between lower density component and higher density component is displaced out of the bowl and harvested. - View Dependent Claims (17, 18)
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Specification