Controlled release of anticancer agents from biodegradable polymers

• US 4,419,340 A
• Filed: 11/20/1980
• Issued: 12/06/1983
• Est. Priority Date: 03/24/1969
• Status: Expired due to Term

• Current Assignee: University of Delaware
• Original Assignee: University of Delaware
• Inventors: Yolles, Seymour
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US06/208,506
• Time in Patent Office: 1,111 Days
• Field of Search: 424/19-22, 424/78, 128/260
• US Class Current: 514/33
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0039 Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

Polymeric articles for controllably dispensing anticancer agents are disclosed which are formed from biodegradable polymeric materials containing the agents.

Claims

1. An implant drug dispensing device article for prolonged administration upon implantation of an anticancer agent which comprises, a solid shaped article formed from a combination of

(a) a biodegradable polymer selected from poly(lactic acid) or polyglycolic acid, and, substantially uniformly and intimately dispersed throughout portions of the article,

(b) cis-dichlorodiammine-platinum (II), and

(c) doxorubicin or cyclophosphamide each being present in administrable doseage being much larger than those normally toxic, to lower than are normally infused by injection, and having an average particle size of from 150 to 425 microns.

2. The article of claim 1 wherein the biodegradable polymer is poly(lactic acid).

3. A method of treating cancer in a mammal susceptible to treatment with cis-dichlorodiammine-platinum (II) comprising implanting an article according to claim 1 into the body of said mammal.