Method and apparatus for detecting sample fluid on an analysis slide
First Claim
1. Apparatus for detecting a sample fluid containing a substantial portion of water on a test element adapted to receive a predetermined quantity of the sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being of a type for the selected analyte and having certain reflectance characteristics, said apparatus comprising:
- means for projecting a beam of radiation comprising wavelengths absorbed by water onto a surface of a test element;
sensor means for detecting the intensity of radiation within the absorption band of water reflected from a surface of a test element and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received before fluid is metered onto an element and a second output after fluid is metered thereon; and
means for processing said outputs, said processing means including means for receiving an input indicative of the reflectance characteristics of said type of test element and for comparing the difference between said first and second outputs with a predetermined value which corresponds to a sufficient amount of fluid on said type of test element, and means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response.
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Accused Products
Abstract
A method and apparatus are disclosed for detecting sample fluid on an analysis slide of the type which is used to perform quantitative analyses. The apparatus comprises means for projecting radiation comprising wavelengths absorbed by water onto the slide and means for measuring the intensity of radiation received from the slide, both before fluid is metered on the slide and after fluid has been metered thereon. The difference between radiation received from a wet slide and from a dry slide is compared with known values to determine if the slide contains sufficient fluid for a suitable test result.
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Citations
20 Claims
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1. Apparatus for detecting a sample fluid containing a substantial portion of water on a test element adapted to receive a predetermined quantity of the sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being of a type for the selected analyte and having certain reflectance characteristics, said apparatus comprising:
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means for projecting a beam of radiation comprising wavelengths absorbed by water onto a surface of a test element; sensor means for detecting the intensity of radiation within the absorption band of water reflected from a surface of a test element and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received before fluid is metered onto an element and a second output after fluid is metered thereon; and means for processing said outputs, said processing means including means for receiving an input indicative of the reflectance characteristics of said type of test element and for comparing the difference between said first and second outputs with a predetermined value which corresponds to a sufficient amount of fluid on said type of test element, and means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for detecting a sample fluid containing a substantial portion of water on an analysis slide, said slide being adapted to receive a predetermined quantity of sample fluid and to produce a response proportional to a selected analyte in the fluid, said slide being selected from more than one type, each type being for a particular analyte and having a defined range of values of reflectivity which varies between a relatively high reflectivity when the slide does not contain any fluid and a relatively low reflectivity after fluid has been deposited on the slide, said method comprising the steps of:
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(a) projecting radiation comprising wavelengths absorbed by water onto a dry slide before the metering of fluid thereon; (b) detecting the intensity of radiation within the absorption band of water reflected from said dry slide; (c) projecting radiation comprising wavelengths absorbed by water onto said slide after the metering of fluid thereon; (d) detecting the intensity of radiation within the absorption band of water reflected from said slide after the metering of fluid onto the slide; (e) comparing the difference between the intensity of radiation reflected from said dry slide and from said slide after fluid has been metered thereon with a predetermined value within the reflectivity range of the type of slide suitable for said selected analyte to determine if sufficient fluid has been metered onto the slide to produce a proper response; and (f) producing a signal in the event the amount of fluid is not sufficient for a proper response. - View Dependent Claims (11, 12)
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13. Apparatus for determining the volume of fluid on an analysis slide which is one of a plurality of types, each type being for a particular analyte and having a defined range of values for reflectivity, said apparatus comprising:
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a radiation source for projecting a beam of radiation comprising wavelengths absorbed by water onto a defined area of a surface of a slide; sensor means for detecting the intensity of radiation reflected from said area and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received from said area before fluid is metered onto a slide and a second output from radiation received from the area after fluid is metered onto a slide; and means for processing said first and second outputs, said processing means including means for storing the range of values which corresponds to the type of slide and for receiving an input indicative of the type of slide, and said processing means having means for comparing the difference between said first and second outputs with the stored range of values and for predicting the volume of fluid on a slide based on the value of said difference. - View Dependent Claims (14, 15, 16)
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17. Apparatus for detecting a sample fluid containing a substantial portion of water on a test element adapted to receive a predetermined quantity of sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being selected from more than one type, each type being for a particular analyte, said apparatus comprising:
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means for projecting a beam of radiation comprising wavelengths absorbed by water onto a surface of an element; sensor means for detecting the intensity of radiation within the absorption band of water reflected from a surface of an element and for producing an output proportional to said intensity, said sensor means being adapted to produce an output after fluid is metered onto a test element; and means for processing said output, said processing means including means for receiving an input indicative of the type of element and for comparing said output with a predetermined value corresponding to a reflectivity which represents a sufficient amount of fluid on a test element, and said processing means having means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response.
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18. Apparatus for detecting a sample fluid containing a substantial portion of water on a test element, said element being adapted to receive a predetermined quantity of sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being selected from more than one type, each type being for a particular analyte, said apparatus comprising:
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means for projecting radiation comprising wavelengths absorbed by water onto an element; sensor means for detecting the intensity of radiation within the absorption band of water received from an element and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received before fluid is metered onto an element and a second output after fluid is metered onto an element; and means for processing said outputs, said processing means including means for receiving an input indicative of the type of element and for comparing the difference between said first and second outputs with a predetermined value which corresponds to a sufficient amount of fluid on an element, and said processing means having means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response. - View Dependent Claims (19, 20)
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Specification