Bipyridine substituted imidazoylidene, copper complex, and its use in food-producing animals

• US 4,421,751 A
• Filed: 04/01/1982
• Issued: 12/20/1983
• Est. Priority Date: 04/01/1982
• Status: Expired due to Term

• Current Assignee: Schering-Plough Animal Health Corporation (Merck & Co., Inc.)
• Original Assignee: International Minerals & Chemical Corp. (The Mosaic Company)
• Inventors: Sundelin, Kurt G. R.
• Primary Examiner(s): Waddell, Frederick E.
• Application Number:
  US06/364,369
• Time in Patent Office: 628 Days
• Field of Search: 424/263, 424/245, 546/9, 546/256, 546/2
• US Class Current: 514/188
• CPC Class Codes: A23K 20/116 Heterocyclic compounds
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: C07D 401/14 containing three or more hetero rings

Abstract

Certain novel bipyridine substituted imidazoylidene compounds, their metal complexes (Cu, Fe and Ni) which are effective to improve feed efficiency and promote growth in food-producing animals, particularly ruminants. The compounds are described by the general formula ##STR1## in which R₁ and R₂ are hydrogen, alkyl or phenyl, and including the cuprous, nickelous and ferrous salts thereof.

Claims

1. A compound of the formula ##STR6## wherein R₁ and R₂ are hydrogen, alkyl or phenyl, and including the cuprous, ferrous and nickelous salts thereof.

5. A growth promoting animal feed additive comprising a compound of claim 1, claim 2, claim 3 or claim 4 in an amount effective to promote animal growth.

2. A compound of the formula ##STR7## in which φ

=phenyl.

6. A growth promoting agent for animals comprising the compound of claim 2 in an amount effective to promote animal growth.

7. The method of promoting growth and enhancing feed efficiency in animals comprising administering to said animals the compound of claim 2 in an amount effective to promote growth.

8. The method of claim 7, in which the animals are ruminants.

9. The method of claim 7, in which the compound is supplied to said ruminants as an oral feed additive in an amount sufficient to obtain a growth response.

10. The method of claim 9, in which the compound is supplied to said ruminants in an amount sufficient to maintain about 75 ppm of said compound in the rumen fluid contents during the growth period of said ruminant.

11. The method of claim 7, in which the animals are poultry.

3. A compound of the formula ##STR8## in which X=Cu++, Fe++, Ni++ and φ

=phenyl.

4. A compound of the formula ##STR9## in which φ

=phenyl.