Composition of matter and process
First Claim
Patent Images
1. A process for preparing a compound of the formulawherein R2 and R3 are hydrogen, alkyl of from 1 to 5 carbon atoms, inclusive, and phenyl;
- R4 is selected from the group consisting of SO2 R2, SO2 CH2 COphenyl, CO2 CH2 Z where Z is selected from the group consisting of CH2 I, CCl3, CH2 SO2 R2, phenyl, and fluorenylmethyl, which comprises reacting a compound of the formula ##STR3## wherein R2, R3, and R4, are as defined above, and X is selected from the group consisting of OSO2 R2, Cl, Br, and I, with triphenylphosphine/carbon tetrahalide, concentrating the reaction mixture in vacuo to a concentrate and applying said concentrate to a thick-layer silica gel plate to give the desired compound.
0 Assignments
0 Petitions
Accused Products
Abstract
Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[ c]-benzo[1,2-b:-4,3-b'"'"']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
14 Citations
1 Claim
-
1. A process for preparing a compound of the formula
wherein R2 and R3 are hydrogen, alkyl of from 1 to 5 carbon atoms, inclusive, and phenyl; - R4 is selected from the group consisting of SO2 R2, SO2 CH2 COphenyl, CO2 CH2 Z where Z is selected from the group consisting of CH2 I, CCl3, CH2 SO2 R2, phenyl, and fluorenylmethyl, which comprises reacting a compound of the formula ##STR3## wherein R2, R3, and R4, are as defined above, and X is selected from the group consisting of OSO2 R2, Cl, Br, and I, with triphenylphosphine/carbon tetrahalide, concentrating the reaction mixture in vacuo to a concentrate and applying said concentrate to a thick-layer silica gel plate to give the desired compound.
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
-
Current AssigneeThe Upjohn Company (Pharmacia Corp.)
-
Original AssigneeThe Upjohn Company (Pharmacia Corp.)
-
InventorsWierenga, Wendell
-
Primary Examiner(s)BRUST, JOSEPH
-
Application NumberUS06/346,461Time in Patent Office687 DaysField of Search548/421US Class Current548/421CPC Class CodesC07D 209/12 Radicals substituted by oxy...C07D 487/06 Peri-condensed systems
