Wet-dry syringe

• US 4,424,057 A
• Filed: 04/01/1982
• Issued: 01/03/1984
• Est. Priority Date: 04/01/1982
• Status: Expired due to Fees

• Current Assignee: Hugh A. House
• Original Assignee: Hugh A. House
• Inventors: House, Hugh A.
• Primary Examiner(s): Yasko, John D.
• Application Number:
  US06/364,496
• Time in Patent Office: 642 Days
• Field of Search: 604/88, 604/201, 604/82, 604/87, 604/200, 604/306, 604/3, 604/205
• US Class Current: 604/88
• CPC Class Codes: A61M 2005/3118 via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
• CPC Class Codes: A61M 5/282 by compression of deformable ampoule or carpule wall
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence
• CPC Class Codes: A61M 5/288 by piercing without internal pressure increase A61M5/283 takes precedence
• CPC Class Codes: A61M 5/3145 Filters incorporated in syringes
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing

Abstract

A wet-dry syringe for combining and mixing a liquid and a solid medicament or at least two dissimilar liquid medicaments prior to the application thereof to a patient includes a first vial having liquid or solid medicament disposed between a pair of identical vial seals. A second vial functions as a piston rod and includes a pair of end seals with a liquid medicament disposed therein. One of the second vial seals includes a hollow piercing needle which when utilized to pierce one end seal of the first vial causes the medicament therein to flow into the first vial thereby mixing the medicaments prior to application to a patient by means of a needle piercing assembly which pierces the second of the first vial seals and the patient to which the mixed medicaments are to be infused. The second vial functions as a piston rod and aides in the discharge of the medicaments.

Claims

1. A wet-dry syringe for combining and mixing a liquid and a solid medicament or at least two dissimilar liquid medicaments prior to the application thereof to a patient comprises, in combination:

(a) an enlongated cylindrically-shaped vial having outwardly extending lip portions proximate each end thereof and a pair of identical vial seals disposed within said cylinder, said vial seals being in intimate frictional contact with the internal walls of said vial and slidable therealong, said vial seals being adapted to retain a first liquid or said solid medicament therebetween;

(b) cap means adapted to be received on each end of said vial to maintain its sterility;

(c) elongated cylindrically-shaped piston rod means;

said piston rod means being hollow and including;

(i) a first piston rod seal disposed proximate one end thereof, said first piston rod seal being in intimate frictional contact with the internal walls of said piston rod means and slidable therealong;

(ii) a second piston rod seal being disposed proximate the other end of said piston rod means in a fixed position, said first and said second piston rod seals being adapted to retain a second liquid medicament therebetween;

(iii) hollow needle means disposed proximate said second piston rod seal, said piston rod means being adapted to be received into said vial for contact with one of said pair of vial seals and when urged into contact with said vial seal causing said hollow needle means to provide a fluid flow path for communication of said second liquid medicament with said solid medicament or said liquid medicament disposed within said vial; and

(d) second needle means having one end adapted to be inserted into a patient and the other end thereof adapted to pierce the other of said pair of vial seals and communicate with said mixed medicaments disposed within said vial, said piston rod means causing said mixed medicaments to be discharged through said second needle means when urged in the direction thereof.

2. A wet-dry syringe according to claim 1 wherein said cap means includes a micropore filter and a third needle means disposed upon one end thereof for piercing one of said vial seals and means for receiving the other end of said second needle means on the other end of said third needle means with said micropore filter being disposed therebetween for causing said mixed medicaments to pass through said micropore filter before entering said patient.

3. A wet-dry syringe according to claim 1 wherein said second needle means is removably retained by said vial lips while piercing the other of said pair of vial seals.

4. A wet-dry syringe according to claim 1 wherein one of said piston rod seals is an integral part of said piston rod means and includes said second needle means, and needle cover means for retaining said liquid medicament in said piston rod means and maintaining the sterility of said second needle means.

5. A wet-dry syringe according to claim 1 wherein said one of said piston rod seals is provided with means for removably affixing a third needle means thereto for piercing said second piston rod seal simultaneously with the piercing of said remaining vial seal and providing a communicating fluid flow path between said second medicament and said first medicament.

6. A wet-dry syringe according to claim 1 wherein said piston rod further includes resilient collapsible membrane means for containing said second liquid medicament disposed between said first and second piston rod seals.

7. A wet-dry syringe according to claim 1 wherein said piston rod means further includes a protruding lip portion disposed proximate said first piston rod seal and a removable end cap adapted to be disposed thereover and cooperate with said protruding lip portion.

8. The method of combining and mixing a liquid and a solid medicament or at least two dissimilar liquid medicaments prior to the application thereof to a patient comprises, the steps of:

(a) providing a vial having identical end seals with a solid or liquid disposed between said seals by a vacuum process;

(b) providing a hollow piston rod having a liquid medicament disposed therein between a fixed and a movable end seal;

(c) providing a hollow piercing means proximate said fixed piston rod seal;

(d) engaging one of said vial seals with said piston rod with said piercing means disposed therebetween;

(e) applying pressure between said piston rod and said vial for said piercing means to puncture said fixed piston rod seal;

(f) drawing said piston rod away from said vial and moving said vial seal proximate one end of said vial, said hollow piercing means providing a fluid flow path between said vial medicament and said piston rod medicament, said piston rod medicament entering said vial because of said pressure differential generated therebetween;

(g) connecting a needle assembly means having a seal piercing means on one end and a patient piercing means on the other end to said vial;

(h) puncturing said remaining vial seal with said needle assembly means; and

(i) applying pressure to said piston rod in the direction of said vial to cause said combined medicament to leave said needle assembly means into said patient.

9. The method of combining and mixing a liquid and a solid medicament according to claim 8 wherein said hollow piercing means is of the dual type having piercing points at both ends and in step (e) said dual piercing means punctures said piston rod seal simultaneously with puncturing said vial seal.