Electrical method and apparatus for non-invasively detecting abnormal flow in conduits

• US 4,425,922 A
• Filed: 04/07/1981
• Issued: 01/17/1984
• Est. Priority Date: 04/07/1981
• Status: Expired due to Fees

• Current Assignee: Alfred Kurtz, Robert J. Kurtz
• Original Assignee: Bioresearch Incorporated
• Inventors: Conti, James C., Strope, Elaine, Findl, Eugene, Griffiths, Cynthia
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): HANLEY, JOHN C
• Application Number:
  US06/251,743
• Time in Patent Office: 1,015 Days
• Field of Search: 128/691, 128/693, 128/713, 128/700, 128/695, 128/696
• US Class Current: 600/504
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves

Abstract

Method and apparatus are disclosed for obtaining flow information of a conductive fluid by detecting the streaming potential and analyzing the resultant signal. In a particular embodiment for detecting abnormal blood velocities in the arterial tree, the apparatus includes a flexible sensor having two fixedly spaced apart electrodes and a common mode signal electrode. Each sensor electrode is connected to an input of a differential amplifier and the common electrode is connected to the common input of the differential amplifier. The output signal from the differential amplifier, after filtering and amplification is provided to a recorder or oscilloscope so that it can be compared with the normal or average signal.

A particular embodiment of the method is used to detect blood flow abnormalities, either too fast or too slow compared with most healthy individuals of the same age. In this method, a flexible sensor having two fixedly mounted electrodes is placed on the skin over the artery to be examined, for example the dorsalis pedis artery, so that each electrode is in electrical contact with a different part of the artery. The detected signal is processed and is compared to normal signals. These comparisons can be the wave shape or the time difference between the detection of the wave pulse and a pump timing signal such as the ECG signal.

Claims

1. Apparatus for non-invasively detecting reduced blood flow downstream of the heart comprising:

means for detecting the streaming potential of an artery and producing a signal in response thereto;

means for detecting the ECG signal; and

means for permitting simultaneous analysis of said streaming potential and said ECG signal.

2. Apparatus as claimed in claim 1 wherein said streaming potential detecting means comprises differential amplifier means;

a first electrode connected to one input of said differential amplifier means;

a second passive electrode connected to a second input of said differential amplifier means; and

a third passive electrode for providing a common mode rejection signal connected to the common connection of said differential amplifier means.

3. Apparatus as claimed in claim 2 and further including means for mounting said first and second electrodes closely spaced to each other and on the surface of the animal being monitored above the artery being monitored.

4. Apparatus as claimed in claim 2 wherein said comparison permitting means permits calculation of the time delay between the R peak of the ECG signal and the peak of the streaming potential signal.

5. Apparatus as claimed in claim 2 wherein said comparison permitting means permits visual observation of the waveform of the streaming potential signal.

6. Apparatus as claimed in claim 5 and further including

a further differential amplifier means;

a fourth passive electrode connected to one input of said further differential amplifier means;

a fifth passive electrode connected to a second input of said further differential amplifier means;

a sixth passive electrode for providing a common mode rejection signal to the common connection of said further differential amplifier means;

said first, second and third electrodes forming a first set of electrodes for detecting streaming potential and said fourth, fifth and sixth electrodes forming a second set of electrodes for detecting a second streaming potential;

first means for attaching said first, second and third electrodes to one general location of the artery in closely spaced relationship to each other;

second means for attaching said fourth, fifth and sixth electrodes to a second general location of the artery in closely spaced relationship to each other;

and wherein said analysis permitting means further permits analysis of characteristics between the signals detected by said first and second sets of electrodes with characteristics between similar signals obtained from a similar artery used as a reference.

7. A passive method for detecting abnormal flow in the arterial tree of an animal, the method comprising:

placing a first passive electrode in electrical contact with a suspect artery;

placing a second passive electrode in electrical contact with the suspect artery, the second electrode being spaced from the first electrode;

detecting an electrical signal between the electrodes, the electrical signal having a voltage component above and below a base line level for the suspect artery;

similarly detecting a similar electrical signal of a reference artery; and

comparing the ratio of the above component to the below component of the detected signal of the suspect artery with the ratio of the above component to the below component of the reference artery.

8. A passive method for detecting abnormal flow in the arterial tree of an animal, the method comprising:

placing a first passive electrode in electrical contact with a suspect artery;

placing a second passive electrode in electrical contact with the suspect artery, the second electrode being spaced from the first electrode;

detecting an electrical signal including a pulse portion;

similarly detecting a similar electrical signal and pulse portion of a reference artery;

detecting a R portion of an ECG signal;

determining a T₂ time difference between the R peak and the subsequently detected pulse portion of the electrical signal from the suspect artery and the reference artery; and

comparing the two T₂ time differences.