Synthetic phospholipid compounds

• US 4,426,330 A
• Filed: 07/20/1981
• Issued: 01/17/1984
• Est. Priority Date: 07/20/1981
• Status: Expired due to Term

• Current Assignee: Surfactant Technologies, Inc.
• Original Assignee: Lipid Specialties, Inc.
• Inventors: Sears, Barry D.
• Primary Examiner(s): Waltz, Thomas A.
• Application Number:
  US06/284,675
• Time in Patent Office: 911 Days
• Field of Search: 260/403
• US Class Current: 554/80
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61K 9/1271 Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers liposome as conjugate A61K47/6911
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07F 9/10 Phosphatides, e.g. lecithin
• CPC Class Codes: C08G 65/3356 having nitrogen in addition to phosphorus

Abstract

Novel synthetic phospholipid compounds, the compounds having the structural formula: ##STR1## where X is a hydrogen or alkyl group, n can vary from about 0 to 200, m can vary from 2 to 10, and R₁ and R₂ are saturated or unsaturated acyl radicals.

Claims

1. A phosphatidyl alkylene oxide compound having the structural formula:

##STR5## where R₁ and R₂ are hydrogen or C₂ -C₂₄ organic acyl radicals;

R₃ is a C₂ -C₃ alkylene radical, X is hydrogen or an alkyl radical, n is a number of from 0 to about 200, and m is a number of from 2 to 10.

2. The compound of claim 1 wherein R₁ and R₂ are C₈ -C₂₀ fatty acid radicals.

3. The compound of claim 1 wherein n is a number of from about 10 to 100.

4. The compound of claim 1 wherein m is two.

5. The compound of claim 1 wherein X is a methyl radical.

6. The compound of claim 1 wherein R₃ is an ethylene radical.

7. The compound of claim 1 wherein X is hydrogen, R₃ is an ethylene radical, n is a number of from 10 to 100, and m is two.

8. The compound of claim 1 wherein the R₁ to R₂ radicals are derived from soy bean.

9. A phosphatidyl polyethylene oxide compound having the structural formula:

##STR6## wherein R₁ and R₂ are hydrogen or C₈ -C₂₀ fatty acid radicals, and n is a number from 0 to abouut 200, and X is hydrogen or alkyl group.