Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections
First Claim
1. An N-formyl peptide-antibiotic complex selected from the group consisting of f-Met-Leu-Phe-R, f-Met-Met-Phe-R, f-Met-Met-Met-R, f-Nle-Leu-Phe-R, f-Met-Leu-Phe-Lys-R, and their pharmaceutically acceptable non-toxic acid addition salts, wherein R is an agent selected from the group consisting of sulfonamide antimicrobial agents, silver containing antimicrobial agents, and antifungal agents.
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Accused Products
Abstract
A group of synthetic N-formyl methionine tri and tetra peptides in covalent combination with antibiotics are useful in treating infections. These peptideantibiotic conjugates exhibit a high degree of chemotactic activity for polymorphonuclear leukocytes and monocytes while simultaneously inhibiting the growth of microorganisms. The use of chemotactic peptide-silver sulfadiazine conjugates is particularly effective for treating burns.
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Citations
15 Claims
- 1. An N-formyl peptide-antibiotic complex selected from the group consisting of f-Met-Leu-Phe-R, f-Met-Met-Phe-R, f-Met-Met-Met-R, f-Nle-Leu-Phe-R, f-Met-Leu-Phe-Lys-R, and their pharmaceutically acceptable non-toxic acid addition salts, wherein R is an agent selected from the group consisting of sulfonamide antimicrobial agents, silver containing antimicrobial agents, and antifungal agents.
- 12. A method of treating burns comprising the application of a pharmacologically effective amount of formyl-methionyl-leucyl-phenylalanine-silver sulfadiazine.
Specification