Nonstress-bearing implantable bone prosthesis

• US 4,430,760 A
• Filed: 12/18/1981
• Issued: 02/14/1984
• Est. Priority Date: 12/18/1981
• Status: Expired due to Fees

• Current Assignee: Collagen Corp. (Abbvie Incorporated)
• Original Assignee: Collagen Corp. (Abbvie Incorporated)
• Inventors: Smestad, Thomas L.
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): ISABELLA, DAVID J
• Application Number:
  US06/332,325
• Time in Patent Office: 788 Days
• Field of Search: 128/92 C, 128/92 G, 128/DIG. 7, 3/1, 3/1.9, 3/1.91, 3/1.4
• US Class Current: 623/10
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/2846 Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2310/00359 Bone or bony tissue
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/365 Bones
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges

Abstract

A flexible, nonstress-bearing bone prosthesis is disclosed that comprises demineralized bone powder contained within a medical grade porous flexible casing made from polymeric fibers or a micro-porous membrane. The pores of the casing are smaller than the particle size of the bone powder but large enough to permit ingress of body cells associated with bone formation.

Claims

1. An implantable nonstress-bearing bone prosthesis comprising particulate demineralized bone, dentin, or mixtures thereof contained within the interior of a medical grade flexible porous closed container made of bioerodible collagen, the pores of which are smaller than the particle size of the particulate demineralized bone or dentin, but large enough to permit passage of osteogenic and/or mesenchymal cells.

2. The implantable nonstress-bearing bone prosthesis of claim 1 wherein the particle size of the particulate demineralized bone or dentin is in the range of about 40 to about 500 microns.

3. The implantable nonstress-bearing bone prosthesis of claim 1 wherein the particle size of the particulate demineralized bone or dentin is in the range of about 75 to 250 microns.

4. The implantable nonstress-bearing bone prosthesis of claim 2 or 3 wherein the size of the pores in the container is about 10-15 microns below the minimum particle size of the demineralized bone.

5. The implantable nonstress-bearing bone prosthesis of claim 1 wherein the container is made from a nonwoven fabric of bioerodible collagen.

6. The implantable nonstress-bearing bone prosthesis of claim 1, 4 or 5 wherein the container is made from crosslinked collagen.