Implantable glucose sensor
First Claim
1. In a method for measuring the glucose content in body fluids by ascertaining the output differential between a pair of adjacent oxygen sensors placed into contact with body fluids, one of said oxygen sensors being unaltered, the other of said oxygen sensors containing glucose oxidase positioned between said other sensor and body fluids placed into contact with said other sensor, whereby the sensor pair measures an oxygen content differential in body fluids placed into contact with the sensor pair, said measured differential corresponding to the extent oxygen in the body fluids has been removed by oxidation of glucose in the body fluids, being thereby a reading for the glucose content in the body fluids, the improvement which comprises measuring the level of oxygen in the body fluids and adjusting said measured differential according to the level of oxygen, whereby the adjusted measured differential constitutes a more accurate reading for the glucose content in the body fluids.
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Abstract
A method and apparatus for more accurate measurements of the glucose content in body fuids by sensing the absolute level of oxygen concentration in the fluid and correcting the output differential measurement indicative of the glucose content in the fluid according to the absolute level of oxygen.
In the two electrode systems known to the art, the unaltered oxygen electrode of the electrode pair may be employed to read the absolute level of oxygen concentration and in addition, function to establish the difference in oxygen concentration caused by glucose oxidation.
In view of the fact that temperature may vary, a thermistor may be included in the electrode system to make temperature corrections for reason that the absolute oxygen reading from either a polarographic or galvanic oxygen electrode is extremely sensitive to temperature and the rate of glucose oxidation is temperature sensitive.
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Citations
8 Claims
- 1. In a method for measuring the glucose content in body fluids by ascertaining the output differential between a pair of adjacent oxygen sensors placed into contact with body fluids, one of said oxygen sensors being unaltered, the other of said oxygen sensors containing glucose oxidase positioned between said other sensor and body fluids placed into contact with said other sensor, whereby the sensor pair measures an oxygen content differential in body fluids placed into contact with the sensor pair, said measured differential corresponding to the extent oxygen in the body fluids has been removed by oxidation of glucose in the body fluids, being thereby a reading for the glucose content in the body fluids, the improvement which comprises measuring the level of oxygen in the body fluids and adjusting said measured differential according to the level of oxygen, whereby the adjusted measured differential constitutes a more accurate reading for the glucose content in the body fluids.
- 5. In a glucose sensor for measuring the glucose content in body fluids comprising a pair of adjacent oxygen sensors, one of said oxygen sensors being unaltered and the other of said oxygen sensors formed into a glucose sensor by inclusion therewith of glucose oxidase positioned between said other sensor and any body fluids placed into contact with said other sensor, said pair of sensors being interconnected to provide an output differential that constitutes a reading for the glucose content in body fluids placed in contact with the pair of sensors, the improvement which comprises having said glucose sensor both to measure the oxygen concentration in body fluids placed in contact with the pair of sensors and to adjust the said output differential of the sensor pair according to the oxygen concentration, whereby a more accurate reading for glucose content is provided.
Specification