Microporous filter system and process

• US 4,431,545 A
• Filed: 05/07/1982
• Issued: 02/14/1984
• Est. Priority Date: 05/07/1982
• Status: Expired due to Fees

• Current Assignee: Pall Corporation (Danaher Corporation)
• Original Assignee: Pall Corporation (Danaher Corporation)
• Inventors: Pall, David B., Krasnoff, Abraham
• Primary Examiner(s): Cintins, Ivars C.
• Application Number:
  US06/376,259
• Time in Patent Office: 648 Days
• Field of Search: 210/641, 210/650, 210/651, 210/654, 210/685, 210/686, 210/806, 210/321.1, 210/321.5, 210/433.2, 210/493.1, 210/493.5, 210/500.2, 210/506, 210/638, 521/27
• US Class Current: 210/641
• CPC Class Codes: A61K 35/16 Blood plasma; Blood serum umbilical cord blood A61K35/51
• CPC Class Codes: A61L 2/0017 Filtration
• CPC Class Codes: A61L 2/022 Filtration
• CPC Class Codes: B01D 39/1623 of synthetic origin
• CPC Class Codes: B01D 61/146 comprising multiple ultrafiltration steps
• CPC Class Codes: B01D 69/12 Composite membranes; Ultra-thin membranes
• CPC Class Codes: B01D 71/56 Polyamides, e.g. polyester-amides
• CPC Class Codes: C02F 1/28 by sorption using ion-exchange C02F1/42; sorbent compositions B01J

Abstract

A microporous filter system comprises two types of hydrophilic, microporous filter media operating in series. The two filter media have opposite zeta potentials with the upstream or first filter medium preferably having the positive zeta potential and the downstream or second filter having the negative zeta potential. The first filter medium typically has an absolute pore rating of from about 0.1 to about 1.0 micrometer and the second or downstream filter medium typically has an absolute pore rating of from about 0.02 to about 0.1 micrometer. The downstream or second filter has a finer absolute pore rating than the upstream or first filter. Fluids contaminated with ultrafine particles can be purified with an essentially absolute efficiency to remove 99.99 percent or more of the particulate matter in the contaminated fluid. The filter system finds particular use in the preparation of ultrapure effluent water of near theoretical resistivity and in the removal of bacteria and endotoxins to form sterile fluids.

Claims

1. A process for the filtration of a contaminated fluid comprising ultrafine particulate material with particle sizes in the range of from about 0.001 to about 10 micrometers said process comprising:

(a) passing said fluid through a first filter medium comprised of a surface modified, hydrophilic, microporous member, said first filter medium further characterized by (i) an absolute pore rating in the range of from about 0.05 to about 1.0 micrometer and (ii) a positive zeta potential, to remove electronegatively charged particulate matter from said fluid; and

(b) then passing said fluid through a second filter medium comprised of a hydrophilic, microporous member, said second filter medium further characterized by (1) an absolute pore rating finer than that of said first filter membrane and in the range of from about 0.01 to about 0.1 micrometer and (ii) a negative zeta potential, to form a filtrate substantially free of (1) both electronegatively and electropositively charged particulate matter, (2) bacteria and endotoxins, and (3) particulate matter greater in size than the absolute pore rating of said second filter medium.

2. The process of claim 1 wherein both said first filter medium and said second filter medium are comprised of nylon 66.

3. The process of claim 2 wherein said second filter medium has an absolute pore rating of from about 0.02 to about 0.06 micrometer.

4. The process of claim 2 wherein said contaminated fluid is water.

5. The process of claim 2 wherein said filtrate is comprised of ultrapure water having an effluent resistivity greater than 14 megaohms/cm.

6. A process for the filtration of a contaminated fluid comprising ultrafine particulate matter with particle sizes in the range of from about 0.001 to about 10 micrometers, said process comprising:

(a) passing said fluid through a first filter medium comprised of a hydrophilic, microporous member said first filter medium further characterized by (i) an absolute pore rating in the range of from about 0.05 to about 1.0 micrometer and (ii) a negative zeta potential, to remove electropositively charged particulate matter from said fluid; and

(b) then passing said fluid through a second filter medium comprised of a surface modified, hydrophilic, microporous member said second filter medium further characterized by (i) an absolute pore rating finer than that of said first filter membrane and in the range of from about 0.01 to about 0.1 micrometer and (ii) a positive zeta potential, to form a filtrate substantially free of (1) both electronegatively and electropositively charged particulate matter, (2) bacteria and endotoxins, and (3) particulate matter greater in size than the absolute pore rating of said second filter medium.

7. The process of claim 6 wherein both said first filter medium and said second filter medium are comprised of nylon 66.

8. The process of claim 7 wherein said second filter medium has an absolute pore rating of from about 0.02 to about 0.06 micrometer.

9. The process of claim 7 wherein said contaminated fluid is water.

10. The process of claim 7 wherein said second filtrate is comprised of ultrapure water having an effluent resistivity greater than 14 megaohms/cm.

11. A filter system comprising, in combination, a first filter medium comprised of a surface modified, hydrophilic, microporous member having a positive zeta potential and an absolute pore rating in the range of from about 0.05 to about 1.0 micrometer and a second filter medium comprised of a hydrophilic, microporous member having a negative zeta potential and an absolute pore rating in the range of from about 0.01 to about 0.1 micrometer and finer than that of said first filter medium.

12. The filter system of claim 11 wherein both said first filter medium and said second filter medium are comprised of nylon 66.

13. The filter system of claim 12 wherein said filter system is formed into a filter element.

14. The filter system of claim 12 wherein said filter system comprises a pleated filter element in cartridge form.

15. The filter system of claim 12 wherein said system is capable of providing a filtrate of ultrapure water having a resistivity greater than 14 megaohms/cm. after a rinse up time of less than 10 minutes.

16. A filter system comprising, in combination, a first filter medium comprised of a hydrophilic, microporous polyamide membrane having a negative zeta potential and an absolute pore rating in the range of from about 0.05 to about 1.0 micrometer and a second filter medium comprised of a surface modified, hydrophilic, microporous polyamide membrane having a positive zeta potential and an absolute pore rating in the range of from about 0.01 to about 0.1 micrometer and finer than that of said first filter medium.

17. The filter system of claim 16 wherein said first filter medium and said second filter medium are comprised of nylon 66.

18. A filter system comprising, in combination, a first filter medium comprised of a surface modified, hydrophilic, microporous polyamide membrane containing quaternary ammonium groups in the hydroxide form and having a positive zeta potential and an absolute pore rating of from about 0.05 to about 1.0 micrometer and a second filter medium comprised of a hydrophilic, microporous polyamide membrane having a negative zeta potential and an absolute pore rating in the range of from about 0.01 to about 0.1 micrometer and finer than that of said first filter medium.

19. The filter system of claim 18 wherein said first filter medium has been contacted with an aqueous solution of ammonium hydroxide to convert said quaternary ammonium group to the hydroxide form.