Mixtures of polymers for medical use

• US 4,433,072 A
• Filed: 04/29/1983
• Issued: 02/21/1984
• Est. Priority Date: 12/15/1978
• Status: Expired due to Term

• Current Assignee: Hospal-Sodip SA
• Original Assignee: Hospal-Sodip SA
• Inventors: Pusineri, Christian, Goletto, Jean
• Primary Examiner(s): Foelak, Morton
• Application Number:
  US06/489,707
• Time in Patent Office: 298 Days
• Field of Search: 523/105, 523/111, 523/112, 523/113, 524/27
• US Class Current: 523/105
• CPC Class Codes: A61L 29/049 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 33/0023 using a quaternized group or a protonated amine group of the substrate
• CPC Class Codes: A61L 33/062 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 2666/14 Macromolecular compounds according to C08L59/00 - C08L87/00; Derivatives thereof
• CPC Class Codes: C08L 27/06 Homopolymers or copolymers of vinyl chloride
• CPC Class Codes: C08L 75/08 from polyethers
• CPC Class Codes: C08L 75/12 from compounds containing nitrogen and active hydrogen, the nitrogen atom not being part of an isocyanate group

Abstract

Polymer compositions of a mixture of vinyl chloride polymer and polyurethane with tertiary amine and/or ammonium groups and heparin.

Claims

1. Polymer compositions, useful especially in the medical field, consisting of a mixture of vinyl chloride polymer and a polyether--urethane with tertiary amine and/or ammonium groups and heparin, with the porportion of the polyether--urethane being from 1 to 99% by weight, relative to the total mixture.

2. The polymer compositions according to claim 1 wherein the ammonium groups are quaternary ammonium groups.

3. Composition according to claim 1, characterised in the at the proportions of polyurethane is between 20 and 60% by weight.

4. Compositions according to claim 1 characterized in that the vinyl chloride polymer comprises at least 60% by weight of chloroethylene units.

5. Compositions according to claim 1 characterised in that the vinyl chloride polymer is a vinyl chloride homopolymer or a vinyl chloride/vinyl ester copolymer.

6. Compositions according to claim 1, characterised in that the polyether-urethanes are polyurethanes comprising oxyalkylene groups.

7. Compositions according to claim 1 characterised in that they satisfy:

m+p≧

0.5 and p+q≧

n-2.5, the letters n, m, p and q respectively denoting;

n;

the number of milliequivalents of oxethylene units-- O--CH₂ --CH₂ --per 100 g of polyurethane,

m;

the number of milliequivalents of tertiary amine groups, which may or may not be salified, per 100 g of polyurethane,

p;

the number of milliequivalents of quaternary ammonium groups per 100 q of polyurethane, and

q;

the number of milliequivalent of ionic groups per 100 g of vinyl chloride polymer.

8. Compositions according to claim 1, characterised in that the polyether-urethanes comprise a plurality of repeat units of the formula:

space="preserve" listing-type="equation">--A--NH--CO--O--B--O--CO--NH-- (I)

and of repeat units of the formula;

space="preserve" listing-type="equation">--A--NH--CO--Z--NH-- (II)

in which formulae;

B is the divalent radical in macrodiol of the polyether type, of the formula;

HO--B--OH,

A is the divalent radical in an aliphatic and/or cycloaliphatic and/or aromatic diisocyanate of the formula;

O═

C═

N--A--N═

C═

O, and

Z is a valence bond or a divalent radical such as;

--NH--NH--CO--, --NH--CH₂ --CO--NH--NH--CO--, --NR₂ --D--NR₃ --CO or --O--M--O--CO--;

R₂, R₃ and M are such that NHR₂ --D--NHR₃ is a primary or secondary diamine and HO--M--OH is a diol.

9. Compositions according to claim 1 characterised in that the proportion of heparin is between 1 and 15%, relative to the polymers.

10. Compositions according to claim 7, characterised in that p₁ -q₁ >

0 and in that the proportion of herparin is between 0.5 and 35% by weight relative to all the polymers, p₁ being the product of p multiplied by the percentage by weight of the polyurethane in the mixture, divided by 100, and q₁ being the product of q multiplied by the percentage by weight of the of the vinyl chloride polymer, with ionic sites, in the mixture, divided by 100.