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Human leukocytic pyrogen test for the detection of exogenous fever-producing substances

  • US 4,434,237 A
  • Filed: 03/31/1982
  • Issued: 02/28/1984
  • Est. Priority Date: 03/31/1982
  • Status: Expired due to Fees
First Claim
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1. A method for determining the pyrogenicity of a substance, comprising the step of:

  • incubating said substance in the presence of a cell mixture for at least 46 hours at 35°

    to 39°

    C., wherein said cell mixture comprises human lymphocytes and human monocytes with a cell ratio of lymphocytes to monocytes of at least 2;

    1 and a composition with respect to the total of all cells present comprising at least 15% monocytes and no more than 10% granulocytes and wherein said cells have a cell contact ratio of from 0.0 to 0.75.

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