Hyperthermia system
First Claim
1. A method of ultrasonically heating a subject volume comprising the steps of:
- providing a transducer;
acoustically coupling a surface of the transducer to the subject volume; and
exciting vibrations within the transducer so that compressional mode vibrations are suppressed over a generally central region of the surface;
the suppression of compressional mode vibrations providing an intensity pattern characterized by relatively low intensities in the regions of the subject volume at depths extending out to a transition distance, with a relatively high intensity on-axis peak in a region beyond the transition distance whereupon a discrete portion of the subject volume may be subjected to considerable heating without appreciable heating of the intervening portions.
1 Assignment
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Accused Products
Abstract
An ultrasonic hyperthermia system capable of producing discrete heating of a volume of deep-seated, normally perfused tissue. An individual transducer is configured and driven so that its compressional mode of vibration is suppressed near the center, with the result that the near field is characterized by the substantial absence of a strong central (on-axis) peak. This is preferably accomplished by driving the transducer at a frequency such that the transverse mode of vibration is responsible for the suppression. The near field transverse intensity distribution is further characterized by an annular satellite peak that surrounds the axis. As one proceeds axially away from the transducer, the satellite peak decreases and a predominant central peak occurs. A plurality of transducers are mounted in an isospherical configuration so that the corresponding plurality of beams are directed toward a central axis of the system. Simultaneous heating of a relatively large cylindrical region is achieved in a system wherein the beams do not actually cross one another, but rather are offset with respect to the central axis. As the beams approach each other, portions of their satellite peaks add to heat the central portion of the cylindrical region while the central peaks heat the outer portion. In the region where the beams converge, the central peaks concentrate the power within the heated cylindrical region.
246 Citations
19 Claims
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1. A method of ultrasonically heating a subject volume comprising the steps of:
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providing a transducer; acoustically coupling a surface of the transducer to the subject volume; and exciting vibrations within the transducer so that compressional mode vibrations are suppressed over a generally central region of the surface; the suppression of compressional mode vibrations providing an intensity pattern characterized by relatively low intensities in the regions of the subject volume at depths extending out to a transition distance, with a relatively high intensity on-axis peak in a region beyond the transition distance whereupon a discrete portion of the subject volume may be subjected to considerable heating without appreciable heating of the intervening portions. - View Dependent Claims (2, 3)
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4. A method of ultrasonically heating a discrete region within a subject volume at a substantial depth therein comprising the steps of:
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providing a transducer; acoustically coupling a surface of the transducer to the subject volume; and exciting compressional vibrations over a generally annular region of the area for propagation into the subject volume; the dimensions of the annular region and the wavelength of ultrasonic vibrations within the subject volume defining a transition distance such that the transverse intensity distributions within the subject volume at depths greater than the transition distance display central high intensity peaks while the transverse intensity distributions within the subject volume at depths less than the transition distance are characterized by the substantial reduction of high peak intensities. - View Dependent Claims (5)
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6. Apparatus for ultrasonically heating a subject volume comprising:
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a transducer; means for acoustically coupling a surface of said transducer to said subject volume; and electrical drive means for applying an alternating voltage to said transducer, thereby exciting vibrations within said transducer so that compressional mode vibrations are induced in said transducer and propagated into said subject volume; said drive means being operable to apply said alternating voltage at a frequency which causes the compressional mode vibrations to be suppressed over a generally central region of the surface, the suppression of compressional mode vibrations providing an intensity distribution characterized by relatively low intensities in the regions of said subject volume at depths extending out to a transition distance, with a relatively high intensity on-axis peak in a region beyond said transition distance whereupon a discrete portion of said subject volume may be subjected to considerable heating without appreciable heating of the intervening portions. - View Dependent Claims (7, 8)
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9. Apparatus for ultrasonically heating a discrete region within a subject volume at a substantial depth therein comprising:
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a plurality of transducer assemblies, each of said transducer assemblies comprising a transducer adapted to be acoustically coupled to said subject volume, and associated drive means for exciting ultrasonic vibrations within said transducer so that when said transducer is acoustically coupled to said subject volume, the vibrations of said transducer cause ultrasonic waves to be propagated into said subject volume, said ultrasonic waves being characterized by an intensity pattern wherein the intensity is relatively low in the regions of the subject volume at depths extending out to a transition distance and wherein the transverse intensity distributions in the regions beyond the transition distance have relatively high intensity peaks; and means for orienting said transducers so that their axes converge toward a central axis into a small region in said subject volume. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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16. A method of ultrasonically heating a discrete region within a subject volume at a substantial depth therein comprising steps of:
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providing a plurality of transducer assemblies, each transducer assembly having an associated transducer; acoustically coupling a surface of each of the transducers to the subject volume; exciting vibrations within each transducer so that compressional mode vibrations are suppressed over a generally central region of the surface of each transducer; the suppression of compressional mode vibrations providing an intensity pattern characterized by relatively low intensities in the regions of the subject volume at depths extending out to a transition distance and further characterized by transverse intensity distributions beyond the transition distance exhibiting relatively high intensity peaks; and orienting said transducers so that the respective axes of the respective directions of vibration propagation generally converge toward a central axis into a small region within the subject volume. - View Dependent Claims (17, 18, 19)
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Specification