(+)-2-[1-(2,6-Dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene and the method for the treatment of human beings suffering from nervous disarrangements, in particular migraine
First Claim
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1. Method for the treatment of human beings suffering from migraine, comprising administering to such human beings between 0.05 to 50 mg of (+)-2-[1-(2.6-dichlorophenoxy)-ethyl]-1.3-diazacyclopent-2-ene per each dose unit or the equivalent amount of a pharmaceutically acceptable acid addition salt thereof.
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Abstract
This invention relates to (+)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene and to pharmaceutically acceptable acid addition salts thereof and the method for the treatment of human beings suffering from nervous disarrangements, in particular migraine, using these compounds.
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Citations
4 Claims
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1. Method for the treatment of human beings suffering from migraine, comprising administering to such human beings between 0.05 to 50 mg of (+)-2-[1-(2.6-dichlorophenoxy)-ethyl]-1.3-diazacyclopent-2-ene per each dose unit or the equivalent amount of a pharmaceutically acceptable acid addition salt thereof.
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2. Method for the treatment of human beings suffering from migraine, comprising administering to such human beings between 0.05 to 50 mg of (+)-2-[1-(2.6-dichlorophenoxy)-ethyl]-1.3-diazacyclopent-2-ene hydrochloride per each dose unit.
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3. A composition for treatment of human beings suffering from migraine comprising (+)-2-[1-(2.6-dichlorophenoxy)-ethyl]-1.3-diazacyclopent-2-ene as the active substance in an amount of 0.05 to 50 mg per dose unit and a pharmaceutically acceptable carrier.
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4. A composition for treatment of human beings suffering from migraine comprising (+)-2-[1-(2.6-dichlorophenoxy)-ethoxy]-1.3-diazacyclopent-2-ene hydrochloride as the active substance in an amount of 0.05 to 50 mg per dose unit and a pharmaceutically acceptable carrier.
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Current AssigneeA Nattermann & CIE GmbH Nattermannallee 1 D-5000 KOLN 30
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Original AssigneeA. Nattermann & Cie. GmbH (Sanofi )
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InventorsBiedermann, Jurgen, Prop, Gerrit, Doppelfeld, Ille-Stephanie
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Primary Examiner(s)Friedman, Stanley J.
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Application NumberUS06/367,944Time in Patent Office735 DaysField of Search424/273 R, 548/359US Class Current514/401CPC Class CodesA61P 25/20 Hypnotics; SedativesC07C 255/00 Carboxylic acid nitriles cy...C07D 233/22 Radicals substituted by oxy...
