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Tumor localization and therapy with labeled antibodies to cell surface antigens

  • US 4,444,744 A
  • Filed: 09/03/1982
  • Issued: 04/24/1984
  • Est. Priority Date: 03/03/1980
  • Status: Expired due to Term
First Claim
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1. A method for detecting and localizing a tumor having on its cell surface a tumor-associated or tumorspecific antigen, which comprises injecting a human subject parenterally with an antibody specific to said antigen and radiolabeled with a pharmacologically inert radioisotope capable of detection using a photoscanning device, and with indifferent immunoglobulin from the same or different species as that used to prepare said specific antibody, said indifferent immunoglobulin being radiolabeled with a different pharmacologically inert radioisotope emitting at an energy capable of independent detection using said photoscanning device, the radiolabeling being so effected that the kinetics and distribution of the radiolabeled specific antibody and indifferent immunoglobulin in said subject are substantially the same during the time period required for scanning;

  • and scanning the subject with said photoscanning device, the level of activity of the labeled indifferent immunoglobulin being used to determine the distribution of background activity due to non-targeted specific antibody, said background activity being subtracted from the total activity of specific antibody, whereby the activity of substantially only the targeted tumor-localized specific antibody is determined and said tumor is thereby detected and localized.

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