Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
First Claim
1. A method of diagnosing the condition of suspected hypoxic-ischemic central nervous sytem tissue of a mammal, comprising:
- (a) providing an oxygenated fluorocarbon emulsion synthetic spinal fluid;
(b) injecting said synthetic spinal fluid into at least a first portion of the cerebrospinal pathway of said mammal to contact said tissue to become a diagnostic fluid;
(c) withdrawing said diagnostic fluid from a second portion of said pathway to create a circulation of said fluid through at least a portion of said pathway;
(d) monitoring the composition of said diagnostic fluid; and
(e) comparing constituents of said fluid for at least a selected difference in the compositions of said synthetic spinal and diagnostic fluids;
whereby said selected differences in said compositions are at least diagnostic of the condition of said suspected hypoxic-ischemic tissue disposed along said portion of said cerebrospinal pathway.
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Abstract
A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.
43 Citations
26 Claims
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1. A method of diagnosing the condition of suspected hypoxic-ischemic central nervous sytem tissue of a mammal, comprising:
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(a) providing an oxygenated fluorocarbon emulsion synthetic spinal fluid; (b) injecting said synthetic spinal fluid into at least a first portion of the cerebrospinal pathway of said mammal to contact said tissue to become a diagnostic fluid; (c) withdrawing said diagnostic fluid from a second portion of said pathway to create a circulation of said fluid through at least a portion of said pathway; (d) monitoring the composition of said diagnostic fluid; and (e) comparing constituents of said fluid for at least a selected difference in the compositions of said synthetic spinal and diagnostic fluids; whereby said selected differences in said compositions are at least diagnostic of the condition of said suspected hypoxic-ischemic tissue disposed along said portion of said cerebrospinal pathway. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification