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Insulin releasing supplier

  • US 4,445,885 A
  • Filed: 09/25/1979
  • Issued: 05/01/1984
  • Est. Priority Date: 02/16/1977
  • Status: Expired due to Term
First Claim
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1. A method for supplying insulin to a patient which comprises connecting the patient to an insulin supplier comprising a casing and at least one tubular structure, said tubular structure being formed of hollow fibers and constituting a polymeric semipermeable membrane comprising a polymer selected from a cellulose, polyvinyl alcohol or polyamide and having pores of 100 Å

  • to 2μ

    in size to provide an internal chamber inside of the tubular polymeric semipermeable membrane and an external chamber outside of the tubular polymeric semipermeable membrane, either the internal chamber or the external chamber having at least one fluid-inlet and at least one fluid-outlet, said hollow fibers having a thickness of about 10 to 50μ and

    an inside diameter of about 50 to 400μ

    , introducing blood or another body fluid of said patient into that chamber which has said at least one fluid-inlet and at least one fluid-outlet and providing an aqueous solution or emulsion of insulin in the other chamber, whereby insulin in an amount required for metabolism within the body is supplied to the blood or the body fluid in response to the blood glucose level through the polymeric semipermeable membrane between the internal and external chambers continually over a period of time.

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