Chewable antacid tablets

• US 4,446,135 A
• Filed: 06/07/1982
• Issued: 05/01/1984
• Est. Priority Date: 06/07/1982
• Status: Expired due to Term

• Current Assignee: Sterling Drug, Inc. (GSK plc)
• Original Assignee: Sterling Drug, Inc. (GSK plc)
• Inventors: Fountaine, Harvey A.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US06/385,913
• Time in Patent Office: 694 Days
• Field of Search: 424/48-58, 424/154-158
• US Class Current: 424/687
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 33/08 Oxides; Hydroxides
• CPC Class Codes: A61K 33/10 Carbonates; Bicarbonates
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Abstract

Chewable calcium carbonate-containing antacid tablets having good "mouthfeel" contain calcium carbonate particles of a particular size in combination with certain excipients.

Claims

1. In a method of imparting good "mouthfeel" in chewable antacid tablets, said good "mouthfeel" being characterized by a non-chalky, non-gritty texture, said tablets being prepared from a primary granulation of tablet ingredients comprising from 45 to 50 weight percent of calcium carbonate and from 8 to 11 weight percent of magnesium hydroxide, as the effective antacid ingredients, along with from 30 to 40 weight percent of sucrose and from 8 to 11 weight percent of mannitol, said primary granulation, together with a flavoring agent and a tablet lubricating agent, being pressed into said chewable tablets, the improvement which comprises use of calcium carbonate having an average particle diameter from 5 to 50 microns to impart said good "mouthfeel" to said chewable tablets.

2. A method according to claim 1 wherein said primary granulation contains from 45 to 47 weight percent of calcium carbonate, from 9 to 10 weight percent of magnesium hydroxide, from 33 to 36 weight percent of sucrose and from 9 to 10 weight percent of mannitol.

3. A method according to claim 2 wherein the calcium carbonate particles have an average diameter of 15 microns.

4. A method according to claim 3 wherein the final tablet mixture contains from 95 to 98 weight percent of the primary granulation, from 1.2 to 2.0 weight percent of a tablet lubricating agent and from 0.2 to 0.5 weight percent of a flavoring agent.

5. A method according to claim 4 wherein the tablet lubricating agent is magnesium stearate and the flavoring agent is mint.