Apparatus and method for measuring blood oxygen saturation

• US 4,447,150 A
• Filed: 02/27/1981
• Issued: 05/08/1984
• Est. Priority Date: 02/27/1981
• Status: Expired due to Term

• Current Assignee: Jostra Bentley, Inc.
• Original Assignee: Bentley Laboratories Incorporated
• Inventors: Heinemann, Stanley O.
• Primary Examiner(s): Punter, William H.
• Application Number:
  US06/236,941
• Time in Patent Office: 1,166 Days
• Field of Search: 356/39-42, 356/408-411, 356/370, 356/445, 356/434-435, 356/432, 356/448, 356/319, 356/321-325, 356/402-407, 356/412-425, 250/205, 250/578, 250/214 C, 250/214 AG, 250/565
• US Class Current: 356/41
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/3612 after treatment
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 2021/3181 using LEDs
• CPC Class Codes: G01N 21/3151 using two sources of radiation of different wavelengths G01N21/33 - G01N21/39 take precedence
• CPC Class Codes: G01N 21/85 Investigating moving fluids or granular solids
• CPC Class Codes: G01N 2201/0621 Supply
• CPC Class Codes: G01N 2201/069 Supply of sources

Abstract

A device and method for measuring blood characteristics and parameters, especially arterial, venous, or differential blood oxygen saturation levels uses one or two probes containing a unique configuration of light emitters of two different wavelengths, and sensors which alternately illuminate and read reflected light from blood passing through a specially-designed cuvette. Electronic comparison of reflected radiation received by the probes produces a voltage which is linearly related to blood oxygen saturation level. An opto-electronic feedback network compensates for differences in blood optical density.

Claims

1. An apparatus for measuring a selected parameter of a blood sample, comprising:

a first radiation source of a first wavelength;

a second radiation source of a second wavelength;

means for positioning said radiation sources to irradiate said sample;

sensor means responsive to radiation from said sources, having an electrical output and positioned to receive radiation from said sources after reflection from said sample and reject other radiation;

means for selectively and adjustably energizing said first radiation source such that the amount of its radiation reflected from said sample and received by said sensor means remains substantially constant regardless of the reflectivity of said sample;

means for selectively and adjustably energizing said second radiation source such that its radiant output is related to the radiant output of said first radiation source;

circuit means for developing a signal related to the ratio of the reflected radiation received by said sensor means from said first and second radiation sources;

circuit means responsive to said signal for producing a resultant signal representative of said selected parameter.

3. The apparatus of claims 1 or 2 wherein the selected parameter is oxygen saturation.

4. The apparatus of claims 1 or 2 further including means for visually displaying said resultant signal.

5. The apparatus of claim 4 wherein said visual display means directly displays the value of said selected parameter.

6. The apparatus of claims 1 or 2 wherein said blood is human blood and said first radiation source has a wavelength in the range of from 8050 Å

to 9200 Å and

said second radiation source has a wavelength in the range of from 6400 Å

to 6800 Å

.

7. The apparatus of claim 6 wherein said first radiation source has a wavelength of 9000 Å

and said second radiation source has a wavelength of 6600 Å

.

8. The apparatus of claim 7 wherein said first and second radiation sources are light emitting diodes.

9. The apparatus of claim 7 wherein said sensor means is a phototransistor.

10. The apparatus of claims 1 or 2 wherein said first and second radiation sources and said sensor means are optically coupled to said sample by fiberoptic means.

19. The apparatus of claims 1, 2, or 11 wherein said first and second radiation sources are alternately selected for equal time periods comprising less than 50% duty cycle, each alternate selection being followed by an equal rest period.

20. The apparatus of claim 19 wherein the periods during which said radiation sources are each selected comprise approximately a 1% duty cycle.

21. The apparatus of claim 19 wherein the frequency of selection of each of said radiation sources is a non multiple of 50 or 60 Hz.

22. The apparatus of claims 1, 2, or 11 wherein said means for adjusting said first radiation source is set to control the depth of photon penetration into said blood sample to an average depth of approximately 3 millimeters.

23. The apparatus of claims 1, 2, or 11 wherein said first and second radiation sources are comprised of a plurality of radiation emitters located around said sensor means.

24. The apparatus of claim 23 wherein said plurality of radiation emitters forms a symmetrical pattern about an axis perpendicular to the direction of blood circulation across said window with said sensor means at the center of said axis across said window and wherein said radiation emitters and said sensor means are substantially in contact with said window.

25. The apparatus of claim 24 wherein said plurality of radiation emitters comprises two of said first wavelength and two of said second wavelength.

26. The apparatus of claim 25 wherein said radiation emitters abut one another in a direction transverse to the direction of blood flow and are spaced approximately 5 millimeters from the center of said sensor means in the direction of blood flow, said radiation emitters of the same wavelength being located diagonally from one another.

2. An apparatus for measuring a selected parameter of a blood sample, comprising:

a first radiation source of a first wavelength;

a second radiation source of a second wavelength;

means for positioning said radiation sources to irradiate said sample;

sensor means responsive to radiation from said sources, having an electrical output and positioned to receive radiation from said sources after transmission through said sample and reject other radiation;

means for selectively and adjustably energizing said first radiation source such that the amount of its radiation transmitted through said sample and received by said sensor means remains substantially constant regardless of the transparency of said sample;

means for selectively and adjustably energizing said second radiation source such that its radiant output is related to the radiant output of said first radiation source;

circuit means for developing a signal related to the ratio of the transmitted radiation received by said sensor means for said first and second radiation sources;

circuit means responsive to said signal for producing a resultant signal representative of said selected parameter.

11. An apparatus for determining the level of oxygen saturation in extracorporeally circulating blood comprising:

a cuvette interposed in the flow path of said blood, having a substantially flat, optically clear window area;

a first radiation source of a first wavelength located proximately to said window;

a second radiation source of a second wavelength located proximately to said window;

sensor means located proximately to said window and responsive to radiation from said first and second radiation sources;

means for selectively and adjustably energizing said first radiation source such that the amount of its radiation reflected from said blood and received by said sensor means remains substantially constant regardless of the reflectivity of said blood;

means for selectively and adjustably energizing said second radiation source such that its radiant output is related to the radiant output of said first radiation source;

circuit means for developing a signal related to the ratio of the reflected radiation received by said sensor means from said first and second radiation sources;

and circuit means responsive to said signal for producing a resultant signal representative of said level of oxygen saturation.

12. The apparatus of claim 11 further including means for visually displaying said resultant signal.

13. The apparatus of claim 12 wherein said visual display means directly displays the oxygen saturation as a percent.

14. The apparatus of claim 13 further including:

a cuvette in both the venous and arterial flow paths;

first and second radiation sources and sensor means in proximate location to said windows of both of said cuvettes;

selection means for selecting measurement of venous or arterial blood oxygen saturation by selectively energizing said first and second radiation sources proximately located to said cuvettes in either the venous or arterial flow paths;

selection means for selecting measurement of venous or arterial blood oxygen saturation;

circuit means for calculating the differential venous and arterial blood oxygen saturation.

15. The apparatus of claims 11, 12, 13 or 14 wherein said blood is human blood and said first radiation source has a wavelength in the range from 8050 Å

to 9200 Å and

said second radiation source has a wavelength in the range of from 6400 Å

to 6800 Å

.

16. The apparatus of claim 15 wherein said first radiation source has a wavelength of 9000 Å

and said second radiation source has a wavelength of 6600 Å

.

17. The apparatus of claim 15 wherein said first and second radiation sources are light emitting diodes.

18. The apparatus of claim 15 wherein said sensor means is a phototransistor.

27. In a blood oxygen saturation meter of the opto-electronic type, including first and second selectively and adjustably energizable light sources of two different wavelengths;

sensor means for receiving light emitted by said sensors and transmitted through a blood sample;

means for adjusting the output level of this second one of said light sources such that its radiant output is related to the radiant output of the first one of said light sources; and

means for determining the ratio of the signals received by said sensor from said light sources;

the improvement comprising;

means for selectively and adjustably energizing said first light source such that the amount of its light transmitted through said blood and received by said sensor means remains substantially constant regardless of the transmissibility of said blood.

28. In a blood oxygen saturation meter of the opto-electronic type, including first and second selectively and adjustably energizable light sources of two different wavelengths;

sensor means for receiving light emitted by said sources and reflected from a blood sample;

means for adjusting the output level of the second one of said light sources such that its radiant output is related to the radiant output of the first one of said light sources; and

means for determining the ratio of the signals received by said sensor from said light sources, the improvement comprising;

means for selectively and adjustably energizing said first light source such that the amount of its light reflected from said blood and received by said sensor means remains substantially constant regardless of the transmissibility or reflectivity of said blood.

29. In a blood oxygen saturation meter of the opto-electronic type, including first and second selectively and adjustably energizable light sources of two different wavelengths;

sensor means for receiving light emitted by said sensors and transmitted through a blood sample;

means for adjusting the output level of this second one of said light sources such that its radiant output is related to the radiant output of the first one of said light sources; and

means for determining the ratio of the signals received by said sensor from said light sources;

the improvement comprising;

means for selectively and adjustably energizing said first light source such that the amount of its light transmitted through said blood and received by said sensor means remains substantially constant regardless of the transmissibility of said blood; and

said first and second light sources are comprised of a plurality of light emitters located around said sensor means.

30. In a blood oxygen saturation meter of the opto-electronic type, including first and second selectively and adjustably energizable light sources of two different wavelengths;

sensor means for receiving light emitted by said sources and reflected from a blood sample;

means for adjusting the output level of the second one of said light sources such that its radiant output is related to the radiant output of the first one of said light sources; and

means for determining the ratio of the signals received by said sensor from said light sources;

the improvement comprising;

means for selectively and adjustably energizing said first light source such that the amount of its light reflected from said blood and received by said sensor means remains substantially constant regardless of the reflectivity of said blood; and

said first and second light sources are comprised of a plurality of light emitters located around said sensor means.

31. A method for measuring a selected parameter of a blood sample, comprising the steps of:

positioning a first radiation source of a first wavelength and a second radiation source of a second wavelength proximately to said sample;

positioning a sensor means, responsive to radiation from said sources and having an electrical output, proximately to said sample to receive radiation from said sources after reflection from said sample;

selectively and adjustably energizing said first radiation source such that the amount of its radiation reflected from said sample and received by said sensor means remains substantially constant regardless of the reflectivity of said sample;

selectively and adjustably energizing said second radiation source such that its radiant output is related to the radiant output of said first radiation source;

developing a signal related to the ratio of the reflected radiation received by said sensor means from said first and second radiation sources;

producing a resultant signal in response to said signal representative of said selected parameter.

33. The method of claims 31 or 32 wherein said selected parameter is oxygen saturation level.

32. A method for measuring a selected parameter of a blood sample, comprising the steps of:

positioning a first radiation source of a first wavelength and a second radiation source of a second wavelength proximately to said sample;

positioning a sensor means, responsive to radiation from said sources and having an electrical output, proximately to said sample to receive radiation from said sources after transmission through said sample;

selectively and adjustably energizing said first radiation source such that the amount of its radiation transmitted through said sample and received by said sensor means remains substantially constant regardless of the transparency of said sample;

selectively and adjustably energizing said second radiation source such that its radiant output is related to the radiant output of said first radiation source;

developing a signal related to the ratio of the transmitted radiation received by said sensor means from said first and second radiation sources;

producing a resultant signal in response to said signal representative of said selected parameter.