Respiratory gas analysis instrument having improved volume calibration method and apparatus

• US 4,448,058 A
• Filed: 07/02/1982
• Issued: 05/15/1984
• Est. Priority Date: 07/02/1982
• Status: Expired due to Fees

• Current Assignee: Sensormedics Corporation (Becton, Dickinson & Co)
• Original Assignee: Sensormedics Corporation (Becton, Dickinson & Co)
• Inventors: Reid, Howard J., Luper, Charles R., Jaffe, Michael B., Mabry, Eric
• Primary Examiner(s): Kreitman, Stephen A.
• Application Number:
  US06/394,608
• Time in Patent Office: 683 Days
• Field of Search: 73/23, 73/1 G, 128/719, 422/84, 436/900, 364/571, 364/497
• US Class Current: 73/23.3
• CPC Class Codes: A61B 5/091 Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• CPC Class Codes: G01F 25/11 using a seal ball or piston in a test loop
• CPC Class Codes: G01N 33/0006 Calibrating gas analysers

Abstract

An improved gas volume calibration method and apparatus for use in respiratory gas analyzers. A control unit monitors the flow of calibration gas through the analyzer by monitoring the electrical signals produced by a gas turbine and a breath switch. During calibration, a known volume of calibration gas is repeatedly delivered to the analyzer from a calibration syringe at each of a number of different flow rates. On the basis of the information received from the turbine and the breath switch, the control unit generates and stores a piecewise linear approximation of the nonlinear characteristic of the turbine. This stored turbine characteristic is then made available during subsequent measurements to eliminate those volume errors which are associated with variations in the rate at which the sample gas is delivered, thereby affording measurements of improved accuracy.

Claims

1. In a gas analysis instrument ofthe type having at least one gas analyzer for measuring the concentration of a component of interest in human breath, and a gas turbine for producing a number of output pulses that varies in accordance with the volume and rate of flow of human breath therethrough, the improvement comprising:

(a) first means for storing a piecewise linear approximation of the response of the gas turbine,

(b) second means responsive to the number of output pulses produced by the turbine for determining the operating point of the turbine on the stored approximation, and

(c) third means responsive to the stored approximation and the output of the second means for providing volume data for a breath.

2. The instrument of claim 1 in which the first means stores the piecewise linear approximation by storing the parameters of the equations for a plurality of linear segments, together with the maximum and minimum values between which respective linear segments are applicable.

3. The instrument of claim 2 in which the approximation gives the number of pulses-per-liter produced by the turbine as a function of the number of pulses-per-second produced thereby.

4. The instrument of claim 3 in which the second means determines said operating point by dividing the total number of turbine output pulses by the time interval during which those pulses occurred to produce a pulses-per-second value.

5. The instrument of claim 4 in which the third means includes (a) means for comparing the pulses-per-second value with said maximum and minimum values to identify the applicable linear segment, (b) means for combining the pulses-per-second signal with the respective linear segment to determine the associated pulses-per-liter value, and (c) means for determining the volume of a breath from said pulses-per-liter value.

6. The instrument of claim 4 in which the third means includes (a) means for combining said pulses-per-second value with the stored approximation to produce a pulses-per-liter value, and (b) means for combining said pulses-per-second value with said pulses-per-liter value to determine the liters-per-second value for a breath.

7. The instrument of claim 1 in which the linear approximation gives the number of pulses-per-liter produced by the turbine as a function of the number of pulses-per-second produced thereby.

8. The instrument of claim 7 including a breath switch connected in series with the gas turbine to produce a signal indicative of the duration of a breath.

9. The instrument of claim 8 in which the second means includes a counter for counting the output pulses produced by the turbine, said counter being enabled by the breath duration signal from the breath switch.

10. The instrument of claim 9 in which the second means includes means for dividing the number of output pulses produced during a breath by the duration of that breath to produce a pulses-per-second value for use in determining said operating point.

11. The instrument of claim 10 in which the third means includes means for determining a pulses-per-liter value from said pulses-per-second value and the stored approximation, and means for combining said pulses-per-liter value with said pulses-per-second value to determine the liters-per-second value for a breath.

12. In a gas analysis instrument of the type having at least one gas analyzer for measuring the concentration of a compound of interest in human breath, and a gas turbine for producing an output signal that varies in accordance with the volume and rate of flow of breath therethrough, the improvement comprising:

(a) first means for storing the information necessary to make available a piecewise linear representation of the response of the gas turbine, said representation relating the volume of breath flowing through the turbine to the rate of flow of that breath therethrough,

(b) a breath switch connected in series with the gas turbine to generate an output signal indicative of the duration of a breath,

(c) second means responsive to the output signal of the turbine and the output signal of the breath switch for determining the rate of flow of a breath, and

(d) third means responsive to the first means and the second means for determining volume data for a breath.

13. The instrument of claim 12 in which the first means stores the piecewise linear representation by storing the parameters of the equations for a plurality of line segments, together with the ranges of flow rates over which those line segments are applicable.

14. The instrument of claim 13 in which the third means determines the volume data for a breath by (a) substituting into one of said equations the rate of flow determined by the second means, and (b) solving said equation for said volume data.

15. The instrument of claim 12 or 14 in which the output signal of the turbine comprises a series of pulses and in which the second means includes (a) a counter for counting the number of pulses produced by the turbine during the time that the breath switch is open, and (b) means for dividing the number in said counter by the time that the breath switch is open to determine the rate of flow of a breath.

16. The instrument of claim 12 including means for storing the information necessary to make available a second piecewise linear representation of the response of an average turbine of the class of turbine to which the gas turbine belongs.

17. The instrument of claim 16 in which the stored piecewise linear representation is derived from the second piecewise linear representation on the basis of volume data taken during calibration.

18. The instrument of claim 12 in which the volume data is the volume of a breath.

19. The instrument of claim 12 in which the volume data is the volume rate of flow of a breath.

20. A method for volume calibrating a gas analysis instrument of the type having (a) a source for providing a known volume of calibration gas, and (b) a gas turbine for providing an output signal that varies in accordance with the volume and rate of flow of gas therethrough, said method including the steps of:

(a) storing a first piecewise linear approximation of the output response of a typical turbine of the class of turbine to which said gas turbine belongs,

(b) directing said known volume of gas through the turbine at a plurality of rates of flow which correspond to a plurality of the linear segments of the piecewise linear approximation and storing data indicative of the resulting turbine output signals,

(c) combining the approximation of step (a) with the data stored during step (b) to produce a second piecewise linear approximation of the output response of the gas turbine, and

(d) making the second piecewise linear approximation available for use in interpreting measurements made by the instrument.

21. The method of claim 20 in which the first stored approximation gives the volume of gas flowing through the turbine as a function of the rate of flow of gas therethrough.

22. The method of claim 20 or 21 in which the first stored approximation is stored by storing the parameters of the equations for a plurality of linear segments, together with the ranges of flow rates over which those linear segments are applicable.

23. The method of claim 22 in which the second approximation is produced by changing the parameters of the equations of the linear segments of the first approximation to reflect the datareceived during step (b).

24. The method of claim 23 in which the data associated with a flow of said known volume of gas through the turbine is accepted for use in producing the second piecewise linear approximation only if the flow rate associated therewith is within a predetermined range of acceptable flow rates.

25. The method of claim 20 in which said known volume of gas is directed through the turbine a plurality of times at each flow rate, and in which said stored data is averaged before being used in producing the second approximation.

26. The method of claim 20 in which the turbine produces an output signal comprising a succession of pulses, and in which the first linear approximation relates the number of pulses per unit volume of gas flow to the number of pulses-per-second of gas flow.

27. The method of claim 26 in which the position of a linear segment of the second linear approximation is determined by (a) measuring the pulses per unit volume that result from the flow of said known volume of gas through the turbine, (b) dividing the total number of pulses that result from the flow of said known volume of gas through the turbine by the duration of said flow to determine a pulses-per-second value, (c) calculating a correction factor from the measured number of pulses per unit volume and the number of pulses per unit volume called for by the first linear approximation at the same pulses-per-second value, and (d) applying said correction factor to one of the linear segments of the first linear approximation to position the corresponding linear segment of the second linear approximation.

28. In a gas volume calibration apparatus for a gas analysis instrument of the typeincluding (a) a source for supplying a known volume of calibration gas, (b) a gas turbine for providing an output signal that varies in accordance with the volume and rate of flow of gas therethrough, and (c) a control circuit connected to the turbine, the improvement characterized by:

(a) means in the control circuit for storing a first piecewise linear approximation of the response of a typical turbine of the class of turbine to which the gas turbine belongs,

(b) means in the control circuit for receiving the output signal of the gas turbine as said known volume of gas is directed therethrough at rates of flow that correspond to at least two different linear segments of the piecewise linear approximation, and

(c) means in the control circuit for modifying said first piecewise linear approximation in accordance with the output signals produced by the turbine during calibration to produce a second piecewise linear approximation of the response of the gas turbine.

29. The calibration apparatus of claim 28 in which the first linear approximation relates the volume of gas flowing through the turbine to the rate of flow of gas therethrough.

30. The calibration apparatus of claim 28 in which the turbine produces an output signal comprising a succession of pulses, and in which the first and second linear approximations relate the pulses-per-liter values for gas flow through the turbine to respective pulses-per-second values.

31. The calibration apparatus of claim 30 in which the first and second linear approximations are stored by storing the parameters of the eauations for a plurality of linear segments, together with the ranges of pulses-per-second values associated with those linear segments.

32. The calibration apparatus of claim 31 in which the parameters of the equations of at least one of the linear segments of the second linear approximation are produced by combining the parameters of the corresponding linear segment of the first linear approximation with a correction factor that is a function of (a) the total number of pulses produced as said known volume of gas flows through the turbine, and (b) the time interval during which the latter pulses occurred.

33. The calibration apparatus of claim 28 in which the first and second linear approximations are stored by storing the parameters of the equations for a plurality of linear segments, together with the ranges of flow rates that are associated with those linear segments.

34. The calibration apparatus of claim 33 in which a parameter of at least one linear segment of the second linear approximation is derived from the parameter of the corresponding linear segment of the first linear approximation by applying a correction factor that is based on the difference between the stored response of a typical turbine and the measured response of the actual turbine.

35. In a gas volume calibration apparatus for respiratory gas analysis instruments of the type including (a) a calibration syringe having a housing and a piston slidably mounted therein, said syringe being adapted to provide a known volume of gas as the piston is moved between predetermined first and second positions, and (b) a gas turbine for providing a number of output pulses that varies in accordance with the rate at which said volume of gas flows therethrough, the improvement characterized by:

(a) a breath switch, connected in series with the turbine, for providing an output signal indicative of the duration of a stroke of the piston,

(b) first means for receiving the turbine output pulses produced during a stroke of the piston and the output signal of the breath switch and for generating an actual flow rate signal indicative of the speed of the stroke,

(c) second means for storing maximum and minimum acceptable values for said flow rate signal, and

(d) third means for comparing the actual flow rate signal with said maximum and minimum acceptable values and for accepting the actual flow rate signal for use in calibrating the instrument only if it compares favorably with said maximum and minimum values.

36. The gas volume calibration apparatus of claim 35 in which maximum and minimum acceptable values are stored for each of a plurality of stroke speeds, and in which the third means compares the actual flow rate signals for a plurality of stroke speeds with respective maximum and minimum acceptable values for those stroke speeds.

37. The gas volume calibration apparatus of claim 36 in which a predetermined number of strokes having acceptable flow rate signals must occur before the instrument is calibrated at the flow rate corresponding to the respective stroke speed.

38. The gas volume calibration apparatus of claim 37 in which the flow rate values of sid predetermined number of strokes are averaged to produce an average flow rate value for use in calibration.

39. The gas volume calibration apparatus of claim 38 in which said average flow rate value, together with the volume of the calibration syringe, determine the position of a line segment that approximates the response of the turbine between said maximum and minimum acceptable values.

40. The gas volume calibration apparatus of claim 36 including an improved calibration syringe having control means for selectably controlling stroke speed.

41. The gas volume calibration apparatus of claim 40 in which the syringe includes an aperture for admitting ambient air into the region behind the trailing edge of the piston, and in which the control means limits the stroke speed of the syringe by limiting the rate at which ambient air can flow through said aperture.

42. The gas volume calibration apparatus of claim 41 in which the control means includes a plate having at least one hole which may be rotated into alignment with said aperture.

43. The gas volume calibration apparatus of claim 35, 40, 41, or 42 in which the syringe is provided with a calibration gas inlet and a calibration gas outlet that are separate from one another, and in which the arrival of the piston in said second predetermined position positively shuts off the flow of calibration gas in at least said outlet.

44. The gas volume calibration apparatus of claim 35 including means for communicating to a user the need for faster strokes if the flow rate signal for a stroke is less than said minimum acceptable value, and for communicating to a user the need for slower strokes if the flow rate signal for a stroke is greater than said maximum acceptable value.

45. The gas volume calibration apparatus of claim 35 or 44 including means for informing a user of the number of acceptable strokes that he has performed.

46. A method for providing volume calibration data to a gas analysis instrument of the type including (a) a calibration syringe for providing a known volume of gas, said syringe having a housing and a piston slidably mounted therein, and (b) a gas turbine for providing a number of output pulses that varies in accordance with the volume and rate of flow of gas therethrough, said method including the steps of:

(a) establishing a plurality of pairs of maximum and minimum acceptable pulses-per-second values corresponding to a pluraliy of flow rates for said known volume of gas through the turbine,

(b) moving the piston in a succession of strokes to cause said known volume of gas to flow through the turbine at a first estimated flow rate,

(c) calculating the pulses-per-second values associated with the strokes of step (b),

(d) comparing the resulting pulses-per-second values to a first pair of maximum and minimum acceptable pulses-per-second values,

(e) storing those pulses-per-second values which compare favorably with said first pair of maximum and minimum acceptable values for use in calibrating the instrument, and

(f) repeating steps (b) through (e) for at least a second estimated flow rate and a second pair of maximum and minimum acceptable pulses-per-second values.

47. The method of claim 46 including the step of calculating the average of the pulses-per-second values for the acceptable strokes performed at each estimated flow rate.

48. The method of claim 47 including the step of determining the coefficient of variation of the pulses-per-second values for the acceptable strokes performed at each estimated flow rate, and rejecting those acceptable values if the coefficient of variation therefor is greater than a predetermined maximum coefficient of variation.

49. The method of claim 46 including the steps of communicating to a user the need for faster strokes if the the pulses-per-second value for a stroke is less than the minimum acceptable value therefor, and of communicating to a user the need for slower strokes if the pulses-per-second value for a stroke is greater than the maximum acceptable value therefor.

50. The method of claim 46 or 49 including the step of counting the number of acceptable strokes and communicating that number to the operator after each stroke.