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NMR System for the non-invasive study of phosphorus metabilism

  • US 4,452,250 A
  • Filed: 04/29/1982
  • Issued: 06/05/1984
  • Est. Priority Date: 04/29/1982
  • Status: Expired due to Term
First Claim
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1. An analytic apparatus for obtaining metabolism information from a living body member comprising a hollow electromagnet having an inner space for receiving the body member, said space having means providing a substantially uniform high-intensity magnetic field and containing a probe coil with which the body member is engageable when received in said space, means generating a radio-frequency signal with a carrier frequency corresponding to the nuclear magnetic resonance frequency of a metabolite in the tissue of the body member, means to repetitively apply short pulses of said radio-frequency signal to said probe coil, whereby to excite nuclear resonance responses of the metabolite, radio frequency demodulation means tuned substantially to said resonance responses, control logic means controlling the application of said radio-frequency signal pulses to said probe coil, circuit means connecting the probe coil to the demodulation means and including switch means, said switch means having transistor controlled means to greatly increase the impedance between the probe coil and the demodulation means responsive to application of said radio-frequency signal pulses, means to substantially remove said impedance after a predetermined period of application of said short pulses to the probe coil, and signal conversion means connected to the output of said demodulation means for converting the output signals of the demodulation means into a representation of the intensities versus frequency shift of the free induction decays of the respective metabolite components of the tissue.

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