Compounds having antibiotic activity, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments

• US 4,459,291 A
• Filed: 07/21/1982
• Issued: 07/10/1984
• Est. Priority Date: 07/22/1981
• Status: Expired due to Fees

• Current Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
• Original Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
• Inventors: Iida, Takao, Shirahata, Kunikatsu
• Primary Examiner(s): Moyer, Donald B.
• Assistant Examiner(s): Faraci, C. Joseph
• Application Number:
  US06/400,537
• Time in Patent Office: 720 Days
• Field of Search: 424/180, 536/18.1, 549/332
• US Class Current: 514/27
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C07D 493/18 Bridged systems
• CPC Class Codes: C07H 17/04 Heterocyclic radicals containing only oxygen as ring hetero atoms
• CPC Class Codes: C12N 1/205 Bacterial isolates
• CPC Class Codes: C12P 19/60 having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin C12P19/605
• CPC Class Codes: C12R 2001/465 Streptomyces

Abstract

New antibacterial compounds, DC--45--A₁ and DC--45--A₂ are produced by fermentation of a microorganism belonging to the genus Streptomyces. The antibiotics are accumulated in the culture liquor and are isolated therefrom. These compounds are also prepared by acid hydrolysis of known compounds, DC--45--A or DC--45--B₂. DC--45--A₂ is also prepared by acid hydrolysis of DC--45--A₁.

Claims

1. A compound of formula I:

##STR13## wherein R represents the group;

##STR14## or a hydrogen atom and the salts thereof chosen from the group consisting of sodium, potassium, calcium, magnesium and aluminium salts.

2. A compound as claimed in claim 1 represented by the formula:

##STR15## or a salt thereof chosen from the group consisting of sodium, potassium, calcium, magnesium and aluminium salts.

3. A compound as claimed in claim 1 represented by the formula:

##STR16## or a salt thereof chosen from the group consisting of sodium, potassium, calcium, magnesium and aluminium salts.

4. A pharmaceutical composition comprising an antibacterial effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier or excipient.

5. A process for inhibiting bacterial growth in a patient or animal in need thereof comprising administering to said patient or animal an antibacterial effective amount of the composition of claim 4.