Pyridyl containing 1,2-benzisothiazole-3-amine derivatives

• US 4,461,901 A
• Filed: 03/04/1983
• Issued: 07/24/1984
• Est. Priority Date: 03/04/1983
• Status: Expired due to Term

• Current Assignee: Wyeth (Pfizer Inc.)
• Original Assignee: American Home Products Corporation (Pfizer Inc.)
• Inventors: Schiehser, Guy A., Strike, Donald P., Potoski, John R.
• Primary Examiner(s): Fan, Jane T.
• Application Number:
  US06/472,404
• Time in Patent Office: 508 Days
• Field of Search: 546/270
• US Class Current: 546/271.1
• CPC Class Codes: C07D 213/73 Unsubstituted amino or imino radicals
• CPC Class Codes: C07D 275/06 with hetero atoms directly attached to the ring sulfur atom
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links

Abstract

Compounds of the formula: ##STR1## wherein X is SO₂, SO or S; and

A is an amine selected from the group: ##STR2## wherein R is hydrogen, (lower)alkyl, (lower)alkoxy or halo; n is 2-4; and

the pharmacologically acceptable salts thereof are disclosed.

Claims

1. A compound having the formula:

##STR11## wherein X is SO₂, SO or S; and

A is an amine selected from the group;

##STR12## wherein R is hydrogen, (lower)alkyl, (lower)alkoxy or halo;

n is 2-4;

or

a pharmaceutically acceptable salt thereof.

2. The compound of claim 1, having the name N-[3-[(2-amino-3-pyridinyl)oxy]propyl]-1,2-benzisothiazol-3-amine 1,1-dioxide.

3. The compound of claim 1, having the name N-[3-[(2-amino-4-pyridinyl)oxy]propyl]-1,2-benzisothiazol-3-amine 1,1-dioxide.