Apparatus for obtaining an objective determination of the rate of oxygen utilization in peripheral tissue

• US 4,463,762 A
• Filed: 03/24/1980
• Issued: 08/07/1984
• Est. Priority Date: 10/18/1977
• Status: Expired due to Term

• Current Assignee: Institute of Applied Biology Special Cancer Research Project
• Original Assignee: Institute of Applied Biology Special Cancer Research Project
• Inventors: Rubens, Harry E.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/132,994
• Time in Patent Office: 1,597 Days
• Field of Search: 128/633, 128/666, 356/39-41, 356/308
• US Class Current: 600/328
• CPC Class Codes: A61B 10/00 Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis vaccination prophylaxis, vaccination therapy A61B17/20; Sex determination; Ovulation-period determination menstruation tables G06C3/00; Throat striking implements
• CPC Class Codes: A61B 90/06 Measuring instruments not otherwise provided for

Abstract

Apparatus employing a non-invasive method for objectively determining in vivo, the rate of oxygen utilization in peripheral tissue by spectral measuring means, containing a light source, a clamp or tourniquet for occluding a segment of blood in the tissue, means for transmitting the light through the isolated segment of blood to pick up the spectral values of the oxyhemoglobin for two selected wavelengths, wherein the rate of reduction of the oxyhemoglobin of the blood as determined at one wavelength is faster that the rate of reduction of the oxyhemoglobin at the other wavelength, means for converting the spectral values individually for the two selected wavelengths into current flow, and means for determining the time-space relationship between the changing spectral values of the two selected wavelengths, from the moment of occlusion.

Claims

1. A non-invasive, spectrometric measuring apparatus for objective in vivo determination of the rate of oxygen utilization in peripheral tissue, comprising:

tissue encircling clamping means for isolating a segment of blood in the tissue of the skin to thereby produce a state of occlusion whereby oxygen absorption may be analyzed,

means for detecting coefficients of absorption for oxyhemoglobin in said tissue in at least first and second wavelength regions after occlusion and during a time interval, said first and second wavelength regions having different rates of change of absorption coefficient when said tissue is in an occluded state, said means for detecting providing electrical output values indicative of the absorption coefficient in said first and second wavelength regions during the time interval, and

means coupled to the output of said detection means for determining the rate of change of said absorption coefficient in said first wavelength region relative to the rate of change of said absorption coefficient in said second wavelength region and for producing an output therefrom which is indicative of the rate of oxygen utilization in said tissue.

2. The apparatus of claim 1, in which the spectral regions are selected in which the coefficients of absorption of one region, become equal to the coefficients of absorption of the other region, and means are provided for measuring the elapsed time after the peripheral tissue is clamped, to the moment when the coefficients become equal.

3. The apparatus of claim 1, in which a recorder is provided for visually registering intermittent scans of the coefficients of absorption of both selected spectral regions of the oxyhemoglobin in the isolated blood;

and said means for determining determines the elapsed time between scans, so that the rate of oxygen utilization can be determined by counting the number of scans from the moment of blood isolation to the registered scan in which the said coefficients of absorption in the registered scan are equal in value.

4. The apparatus of claim 1, provided with a timer;

means for starting the timer at the moment of blood isolation; and

electronic means for comparing the electrical values corresponding to the spectral values of the coefficients of absorption of both spectral regions; and

means for indicating on the timer when the coefficients of absorption of both selected regions are equal in value.

5. The apparatus of claim 1, provided with a comparator for comparing the electrical values of the changing coefficients of the two spectral regions;

and means for controlling an electric timer to record the time from the moment of blood isolation to the moment of equalization of the coefficients of absorption of the two spectral regions.

6. The apparatus of claim 1, in which a timer is provided for registering the time that has elapsed from the moment of blood isolation to the moment when the coefficients of absorption of the two spectral regions are equalized.

7. The apparatus of claim 1, in which a timer is provided;

means for starting the timer at the moment of blood isolation; and

means for stopping the timer when the coefficients of absorption of the two spectral regions are equalized.

8. The apparatus of claim 1, in which the spectrometric measuring apparatus includes a light source, and means are provided for discontinuing the light source when the clamping means is released.

9. The apparatus of claim 1, in which the spectrometric measuring apparatus includes a light source, and means are provided for starting the light source when the clamp is applied to the tissue.

10. The apparatus of claim 1, in which the spectrometric measuring apparatus includes includes two light measuring means for detecting light in the spectral regions of 565 and 578 nanometers.