Blood glucose control apparatus and method
First Claim
1. In an apparatus for controlling the concentration of glucose in the blood stream of a subject at a desired level (BI) having means for controlling the infusion rate of insulin as a function of the periodically measured blood glucose concentration (G) and a predetermined basal infusion rate (RI) for the desired level, the improvement comprising means for periodically searching for and determining the basal infusion rate RI for the desired level in accordance with:
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space="preserve" listing-type="equation">RI=RI.sub.LAST (GY/BI)said means for searching and determining including means for determining the present blood glucose concentration value (GY), means for fitting a plurality of blood glucose concentrations (G) to a least squares regression line and for determining if the slope of the least squares regression line fit for the least five G values is less than 0.5 and if GY is within ±
50% of the desired BI level, said means for searching and determining conducting searches at periods equal to or greater than the period between glucose measurements.
1 Assignment
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Accused Products
Abstract
In a method and apparatus for controlling the concentration of glucose in the blood stream of a subject at a desired level (BI) including controlling the supply of insulin (IR) by periodically measuring the blood glucose concentration (G) and selecting a predetermined basal infusion rate (RI) for the desired level, the step of selecting a predetermined basal infusion rate comprises periodically searching for the value of the basal infusion rate RI required for BI in accordance with
RI=RI.sub.LAST (GY/BI)
where (GY) is the present blood glucose level corrected to fit a least squares regression line, when the slope of the least squares regression line fit for the last five G values is less than 0.5 and GY is within ±50% of the desired BI level, and wherein the period between searches is equal to or greater than the period between glucose measurements.
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Citations
4 Claims
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1. In an apparatus for controlling the concentration of glucose in the blood stream of a subject at a desired level (BI) having means for controlling the infusion rate of insulin as a function of the periodically measured blood glucose concentration (G) and a predetermined basal infusion rate (RI) for the desired level, the improvement comprising means for periodically searching for and determining the basal infusion rate RI for the desired level in accordance with:
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space="preserve" listing-type="equation">RI=RI.sub.LAST (GY/BI)said means for searching and determining including means for determining the present blood glucose concentration value (GY), means for fitting a plurality of blood glucose concentrations (G) to a least squares regression line and for determining if the slope of the least squares regression line fit for the least five G values is less than 0.5 and if GY is within ±
50% of the desired BI level, said means for searching and determining conducting searches at periods equal to or greater than the period between glucose measurements. - View Dependent Claims (2)
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- 3. In a method for controlling the concentration of glucose in the blood stream of a subject at a desired level (BI) including controlling the supply of insulin by periodically measuring the blood glucose concentration (G) and selecting a predetermined basal infusion rate (RI) for the desired level, the improvement wherein the step of selecting a predetermined basal infusion rate comprises periodically searching for and determining the value of the predetermined basal infusion rate RI required for BI in accordance with
- space="preserve" listing-type="equation">RI=RI.sub.LAST (GY/BI)
said steps of searching and determining including determining the present blood glucose concentration (GY), fitting a plurality of blood glucose determinations (G) to a least squares regression line, determining if the slope of the least squares regression line fit for the last five G values is less than 0.5 and if GY is within ±
50% of the desired BI level, said steps of searching and determining being conducted at periods equal to or greater than the period between glucose measurements.- View Dependent Claims (4)
Specification