Blood purification apparatus

• US 4,469,593 A
• Filed: 03/09/1983
• Issued: 09/04/1984
• Est. Priority Date: 03/10/1982
• Status: Expired due to Term

• Current Assignee: Kenji Maeda, Kabushiki Kaisha Toyota Chuo Kenkyusho (Toyota Motor Corporation)
• Original Assignee: Kenji Maeda, Kabushiki Kaisha Toyota Chuo Kenkyusho (Toyota Motor Corporation)
• Inventors: Kitano, Tomoyuki, Maeda, Kenji, Shinzato, Toru, Ishihara, Toshikazu
• Primary Examiner(s): Adee, John
• Application Number:
  US06/473,574
• Time in Patent Office: 545 Days
• Field of Search: 210/739-748, 210/96.2, 210/104, 210/87, 210/188, 210/321.1
• US Class Current: 210/96.2
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/3403 Regulation parameters
• CPC Class Codes: A61M 1/3406 Physical characteristics of the filtrate, e.g. urea
• CPC Class Codes: A61M 1/341 by measuring the filtrate rate or volume
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3427 back through the membrane, e.g. by inverted trans-membrane pressure [TMP]
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3441 Substitution rate control as a function of the ultrafiltration rate
• CPC Class Codes: A61M 1/3451 the difference in weight between both ultra-filtrate and substitution reservoir being used as control signal
• CPC Class Codes: A61M 1/3458 having electrolytes not present in the dialysate
• CPC Class Codes: A61M 1/3609 Physical characteristics of the blood, e.g. haematocrit, urea
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/3669 Electrical impedance measurement of body fluids; transducers specially adapted therefor
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3372 Temperature compensation
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2230/207 hematocrit

Abstract

A blood purification apparatus includes an extracorporeal circulation system, a blood purifier provided in the system for purifying blood by dialysis or filtration through a semipermeable membrane, a circulation blood volume measuring instrument for measuring changes in a circulating blood volume within a patient'"'"'s body, a control section comprising a memory for storing a program for a pattern of changes in the circulating blood volume during blood purification, the program being matched to the condition of a patient, and a regulator connected to the extracorporeal circulation system and the control section, for controlling the circulating blood volume, the regulator being controlled by the control section on the basis of the circulating blood volume measured during blood purification and the programmed amount. In this apparatus, optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.

Claims

1. A blood purification apparatus comprising:

an extracorporeal circulation system, a blood purifier provided in said system for purifying blood by dialysis or filtration through a semipermeable membrane,

a circulating blood volume measuring instrument connected to said extracorporeal circulation system for measuring changes in the circulating blood volume within a patient'"'"'s body,

a control section connected to said circulating blood volume measuring instrument, comprising a memory for storing a program for a pattern of changes in the circulating blood volume during blood purification, said program being matched to the condition of the patient, and

a regulator connected to said extracorporeal circulation system and said control section, for controlling the circulating blood volume, said regulator being controlled by said control section on the basis of the circulating blood volume measured during blood purification and the programmed amount,

whereby optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.

2. An apparatus according to claim 1, further comprising a water removal quantity measurement device for measuring the amount of water removed from the patient'"'"'s body connected to said control section, wherein said control section further comprises a water removal quantity memory for storing a water removal program and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification and the measured quantity of removed water with programmed values.

3. An apparatus according to claim 1 wherein said regulator comprises a total body fluid volume change regulator.

4. An apparatus according to claim 2, wherein said regulator comprises a total body fluid volume change regulator.

5. An apparatus according to claim 1, wherein said regulator comprises a plasma osmotic pressure regulator.

6. An apparatus according to claim 5, further comprising a plasma osmotic pressure measurement device for substantially measuring the osmotic pressure of the plasma of the patient, connected to said extracorporeal circulation system, and said control section further comprises a plasma osmotic pressure memory for storing a prescribed value of plasma osmotic pressure and controls said regulator on the basis of a comparison of the circulating blood volume measured during purification with the programmed amount and of the measured plasma osmotic pressure with the prescribed value.

7. An apparatus according to claim 5, further comprising a water removal quantity measurement device for measuring the amount of water removed from the patient'"'"'s body, wherein said control section further comprises a water removal quantity memory for storing a water removal program, and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification with the programmed amount, of the measured plasma osmotic pressure with the prescribed value, and of the measured amount of removed water with the programmed amount.

8. An apparatus according to claim 5, wherein said plasma osmotic pressure regulator comprises a means for controlling the infusing rate of osmolal solution to control the plasma ocmotic pressure.

9. An apparatus according to claim 5, wherein said plasma osmotic pressure regulator comprises a means for varying the electrolytic concentration of plasma.

10. An apparatus according to claim 6, wherein said plasma osmotic pressure mmeasurement device comprises a means for measuring the electrolytic concentration of the plasma.

11. An apparatus according to claim 10, wherein said plasma osmotic pressure measurement device comprises at least one ion electrode for measuring the concentration of a specific ion in the plasma.

12. An apparatus according to claim 10, wherein said plasma osmotic pressure measurement device comprises a means for measuring the electrolytic concentration of the plasma from its electrical resistivity.

13. An apparatus according to claim 3, wherein said total body fluid volume change regulator comprises a water removal regulator.

14. An apparatus according to claim 1, wherein said circulating blood volume measuring instrument is a hematocrit measuring instrument which detects changes in the circulating blood volume as changes in the hematocrit.

15. An apparatus according to claim 14, wherein said hematocrit measuring instrument comprises a resistivity measurement device for measuring the electrical resistivity of the blood in said extracorporeal circulation system, a temperature compensator for compensating the measured resistivity for temperature, and an arithmetic circuit for calculating the hematocrit from the electrical resistivity.

16. An apparatus according to claim 14, wherein said hematocrit measuring instrument comprises a resistivity measuring device for measuring the electrical resistivity of the blood in said extracorporeal circulation system, a temperature compensator for compensating the measured resistivity for temperature and an arithmetic circuit for calculating the hematocrit from the electrical resistivity, and the resistivity measurement device has a measurement cell including at least one pair of electrodes provided in an insulative pipe communicating with said extracorporeal circulation system at positions symmetrically opposed with respect to the axis of thee insulative pipe and separated from each other by a prescribed distance in the axial direction of said insulative pipe.

17. An apparatus according to claim 14, wherein said hematocrit measuring instrument comprises a resistivity measuring device for measuring the electrical resistivity of the blood in said extracorporeal circulation system and electrical resistivity of the plasma component of the blood, temperature compensators for compensating the measured resistivity for temperature and an arithmetic circuit for calculating the hematocrit from the electrical resistivity, and the hematocrit is calculated from both the electrical resistivity of the blood and the electrical resistivity of the plasma component.

18. An apparatus according to claim 16, wherein said resistivity measurement device is further provided with a measurement cell for measuring the electrical resistivity of the plasma component of the blood, and the hematocrit is calculated from both the electrical resistivity of the blood and the electrical resistivity of the plasma component.

19. An apparatus according to claim 17, wherein a filter is provided for ultrafiltrating a portion of the plasma from said extracorporeal circulation system and the measurement cell for measuring the electrical resistivity of the plasma component is provided in a waste filtrate path of said filter.

20. An apparatus according to claim 18, wherein a filter is provided for ultrafiltrating a portion of the plasma from said extracorporeal circulation system and the measurement cell for measuring the electrical resistivity of the plasma component is provided in a waste filtrate path of said filter.

21. An apparatus according to claim 20, further comprising:

a water removal quantity measurement device for measuring the amount of water removed from the patient'"'"'s body, connected to said control section, and

a plasma osmotic pressure measurement device for substantially measuring the osmotic pressure of the plasma of the patient, connected to said extracorporeal circulation system and said control section, said resistivity measurement device having a measurement cell including two pairs of electrodes,

wherein said regulator comprises a total body fluid volume change regulator and a plasma osmotic pressure regulator, and

said control section further comprises a water removal quantity memory for storing a water removal program, and a plasma osmotic pressure memory for storing a prescribed value of plasma osmotic pressure and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification with the programmed amount, of the measured plasma osmotic pressure with the prescribed value, and of the measured amount of removed water with the programmed amount.

22. An apparatus according to claim 1, wherein said regulator comprises a total body fluid volume change regulator and a plasma osmotic pressure regulator.

23. An apparatus according to claim 22, further comprising a plasma osmotic pressure measurement device for substantially measuring the osmotic pressure of the plasma of the patient, connected to said extracorporeal circulation system, and said control section further comprises a plasma osmotic pressure memory for storing a prescribed value of plasma osmotic pressure and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification with the programmed amount and of the measured plasma osmotic pressure with the prescribed value.

24. An apparatus according to claim 3, wherein said total body fluid volume change regulator comprises a means for infusing a replacement fluid into said extracorporeal circulation system.

25. An apparatus according to claim 16, wherein said resistivity measurement device has a measurement cell including two pairs of electrodes.