Polymeric diffusion matrix
First Claim
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1. A transdermal drug delivery vehicle, which contains α
- -[1-(methylamino)ethyl]benzene-methanol in the form of a shape-retaining matrix for direct application to the skin of a patient in need of the α
-[1-(methylamino)ethyl]benzene-methanol to be delivered, said matrix comprising from about 2 to about 60% glycerol, from about 2 to about 15% polyvinylalcohol molecular weight of from about 100,000 to about 150,000, from about 2 to about 10% polyvinylpyrrolidone molecular weight of from about 20,000 to about 60,000 and the balance water, cast or molded from hot solution thereof.
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Abstract
A polymeric diffusion matrix is provided comprising from about 2 to about 60% glycerol, from about 2 to about 15% polyvinylalcohol, from about 2 to about 10% water soluble polymer with hydration sites which in combination with the remaining ingredients yields a matrix capable of sustained release of a drug dispersed therein, and the balance water, the percentages being by weight.
87 Citations
7 Claims
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1. A transdermal drug delivery vehicle, which contains α
- -[1-(methylamino)ethyl]benzene-methanol in the form of a shape-retaining matrix for direct application to the skin of a patient in need of the α
-[1-(methylamino)ethyl]benzene-methanol to be delivered, said matrix comprising from about 2 to about 60% glycerol, from about 2 to about 15% polyvinylalcohol molecular weight of from about 100,000 to about 150,000, from about 2 to about 10% polyvinylpyrrolidone molecular weight of from about 20,000 to about 60,000 and the balance water, cast or molded from hot solution thereof. - View Dependent Claims (2, 3, 4)
- -[1-(methylamino)ethyl]benzene-methanol in the form of a shape-retaining matrix for direct application to the skin of a patient in need of the α
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5. A method of delivering α
- -[1-(methylamino)ethyl]benzene-methanol to a patient over a prolonged period of time at a steady rate which comprises applying to the skin of said patient a transdermal drug delivery vehicle, which contains α
-[1-(methylamino)ethyl]benzene-methanol in the form of a shape-retaining matrix for direct application to the skin of a patient in need of α
-[1-methylamino)ethyl]benzene-methanol, said matrix comprising from about 2 to about 60% glycerol, from about 2 to about 15% polyvinyl alcohol molecular weight of from about 100,000 to about 150,000, from about 2 to about 10% polyvinylpyrrolidone molecular weight of from about 20,000 to about 60,000 and the balance water, cast or molded from hot solution thereof. - View Dependent Claims (6, 7)
- -[1-(methylamino)ethyl]benzene-methanol to a patient over a prolonged period of time at a steady rate which comprises applying to the skin of said patient a transdermal drug delivery vehicle, which contains α
Specification