Blood bank cuvette cassette and label therefor

• US 4,472,357 A
• Filed: 11/18/1981
• Issued: 09/18/1984
• Est. Priority Date: 11/18/1981
• Status: Expired due to Term

• Current Assignee: MLA Systems Incorporated
• Original Assignee: Medical Laboratory Automation Incorporated
• Inventors: Scordato, Richard E., Levy, Didya D.
• Primary Examiner(s): Turk, Arnold
• Application Number:
  US06/322,639
• Time in Patent Office: 1,035 Days
• Field of Search: 422/58, 422/102, 356/246, 206/443, 206/459, 206/524.3, 206/524.4, 206/820, 428/35, 128/763, 128/764, 128/765, 128/272, 128/762, 128/771, 40/2 R, 40/312, 220/23.4, 604/403, 604/404
• US Class Current: 604/403
• CPC Class Codes: B01L 3/5453 for test tubes
• CPC Class Codes: G01N 33/80 involving blood groups or blood types or red blood cells white blood cells G01N33/56972
• CPC Class Codes: Y10S 206/82 Separable, striplike plural articles

Abstract

A plurality of cuvettes joined together by breakable links between each cuvette for use in testing blood for its ABO classification and the presence of a typical antibodies, and for crossmatching blood for compatibility, together with label means for indicating the reagents used in each cuvette and the identity of the person whose blood is being tested. The cuvettes may be adapted to accept a closure means which permits the cuvettes to be pre-packaged with reagents required to carry out blood tests. The cuvettes have a hydrophilic polymer coating thereon that is non-destructive of red blood cells.

Claims

1. An article of manufacture comprising a thermoplastic container for storing or holding human blood characterized in that the blood contacting surface thereof is provided with a hydrophilic coating comprising a polymer formed of a redox catalyst of sodium metabisulfite and ammonium persulfate and a monomer of 2-hydroxyethyl methacrylate that has been diluted in neat isopropanol to a solids content of approximately 3/4% to 1% by weight to provide the coating solution, which polymer is non-destructive of red blood cells.

2. An article of manufacture according to claim 1 wherein the polymer is formed by adding a diluent of 95% isopropanol and 5% water on a volume basis to the monomer 2-hydroxyethyl methacrylate on a monomer to diluent weight ratio of 20:

80, then adding a redox catalyst of sodium metabisulfite and ammonium persulfate having a 1;

1 weight ratio to the monomer mixture in a 1;

100 (redox;

monomer) weight ratio, and then diluting the polymer thus formed in neat isopropanol to a solids content of approximately 3/4% to 1% by weight to provide the coating solution.

3. An article of manufacture comprising a plurality of thermoplastic elongated cylindrical test-tube like cuvette means integrally formed into a linear group of individual cuvette means with adjacent cuvette means connected together by a frangible member, each frangible member being a single element breakable along a line parallel to the longitudinal axis of a cuvette means, wherein each cuvette means is provided adjacent its upper end with a flat surface substantially tangent to the outer surface of said cuvette means and having a width approximately equal to the diameter of the cuvette means, the flat surface of each cuvette means forming a co-planar array of spaced apart flat surfaces adapted to receive a single label bearing blocks of data separated by perforation means such that each perforation means will align with a space between said flat surfaces and each block of data can be secured to the flat surface of an individual cuvette means, and wherein the interior surface of each cuvette means comprises a hydrophilic polymer coating formed of a redox catalyst of sodium metabisulfite and ammonium persulfate and a monomer of 2-hydroxyethyl methacrylate that has been diluted in neat isopropanol to a solids content of approximately 3/4% to 1% by weight to provide the coating solution, which polymer does not lyse red blood cells nor potentiate false antigen antibody reactions.

4. An article of manufacture according to claim 3 wherein the polymer is formed by adding a diluent of 95% isopropanol and 5% water on a volume basis to the monomer 2-hydroxyethyl methacrylate on a monomer to diluent weight ratio of 20:

80, then adding a redox catalyst of sodium metabisulfite and ammonium persulfate having a 1;

1 weight ratio to the monomer mixture in a 1;

100 (redox;

monomer) weight ratio, and then diluting the polymer thus formed in neat isopropanol to a solids content of approximately 3/4% to 1% by weight to provide the coating solution.

5. An article of manufacture according to claim 3 including label means adapted for attachment to said plurality of cuvette means, said label means containing blocks of data each containing different reagent information and a common patient identification indicia so that, when said label means is attached to said plurality of cuvette means, a block of data aligned with a cuvette means includes information as to the reagent used in that cuvette means for a blood bank test and the patient identification indicia.

6. An article of manufacture according to claim 5 wherein said label means is provided with transverse rows of perforations separating each block of data from the adjacent block of data, said rows of perforations being spaced from each other so as to be in alignment with the lines along which the frangible members connecting individual cuvette means break when the label means is attached to the plurality of cuvette means so that when said cuvette means are separated into individual or a sub-group cuvette means said label means will tear along the row of perforations aligned with the broken frangible member.

7. An article of manufacture according to claim 5 including a plurality of different test reagents, one in each of said cuvette means, the reagent in a cuvette means conforming to the reagent information on the part of the label means aligned with that cuvette means, and separate sealing means closing each cuvette means.