Self-driven pump assembly and method of operation

• US 4,474,575 A
• Filed: 09/22/1982
• Issued: 10/02/1984
• Est. Priority Date: 02/01/1982
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B., Peery, John R., Place, Virgil A.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Lester, Michelle N.
• Application Number:
  US06/421,597
• Time in Patent Office: 741 Days
• Field of Search: 604/890-892, 604/896, 604/51-53, 604/93, 604/131, 604/150, 604/151, 604/174, 604/179, 604/180, 604/96
• US Class Current: 604/131
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons

Abstract

A pump assembly particularly useful as an infusor for parenteral administration of a small amount of a therapeutically active substance for a prolonged period of time at a substantially constant rate comprising a fluid imbibing pump mounted within a receptacle into which actuating fluid may be charged. The active agent is dispensed from the pump after the pump is exposed to the fluid. Means to vary or stop the pump by obdurating all or a portion of the exterior surface of the pump can also be provided. Variation in flow rates can also be obtained by changing the composition of the actuating fluid.

Claims

1. A pump assembly for the delivery of a quantity of fluid over a prolonged period of time comprising, in combination:

(a) fluid imbibing pump means for discharging a predetermined volume of fluid, said pump means having an external surface at least a portion of which is permeable to an actuating fluid,

(b) fluid impermeable container means receiving said fluid imbibing pump means in fluid sealing relationship with the exterior surface thereof, whereby a fluid receiving volume is defined between the actuating fluid permeable portion of the exterior surface of said fluid imbibing pump means and the interior of said container means and;

(c) means for adjustably varying the area of the actuating fluid permeable portion of said fluid imbibing pump means exposed to actuating fluid contained within said container means.

2. The pump assembly of claim 1 further comprising vacuum release means in the wall of said container means.

3. The pump assembly of claim 1 wherein at least a portion of said container means is defined by a flexible collapsible wall portion having a collapse capacity at least equal to the volume of the contents of said pump to be discharged whereby imbibition of fluid during actuation of said pump will not create a vacuum on said pump.

4. The pump assembly of claim 1, 2 or 3 further comprising an actuating fluid for said fluid imbibing pump means contained within the volume defined between said pump and said container.

5. The pump assembly of claim 1 wherein the means for adjustably varying the area of said fluid imbibing pump means exposed to actuating fluid comprises means for adjustably obstructing the surface of the actuating fluid permeable portion of the exterior surface of said pump means.

6. The pump assembly of claim 1 wherein the means for adjustably varying the area of said fluid imbibing pump means exposed to actuating fluid comprises movable, fluid sealing means disposed around said pump means and in sealing relationship to said container means.

7. The pump assembly of claim 1, 2, 3, 5 or 6 further comprising a fluid to be pumped within said fluid imbibing pump means.

8. The pump assembly of claim 1, 2, 3, 5 or 6 further comprising fluid communicating means for conducting fluid from said fluid imbibing pump to a situs of use.

9. The pump assembly of claim 1, 2, 3, 5 or 6 for use as an infusor wherein the fluid imbibing pump is in fluid communicating relationship with means for introducing the fluid to be pumped into the interior of an animal and said material to be pumped is contained within said fluid imbibing pump means and comprises a beneficial active agent.

10. The pump assembly of claim 9 further comprising means for attaching said pump assembly to an external body surface of said animal.

11. The pump assembly of claim 9 wherein said material to be pumped is a beneficial active agent and the fluid communicating means conducts fluid from the interior of said fluid imbibing pump to the interior of the urinary bladder of an animal.