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Synthetic vaccine and process for producing same

  • US 4,474,757 A
  • Filed: 12/29/1981
  • Issued: 10/02/1984
  • Est. Priority Date: 01/13/1981
  • Status: Expired due to Fees
First Claim
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1. A synthetic vaccine against a plurality of differing influenza virus infections comprising a suitable macromolecular carrier having attached thereto a synthetic peptide corresponding to an antigenic fragment of the hemagglutinin component of an influenza virus, which antigenic fragment is common to a plurality of differing influenza virus strains and capable of eliciting antibodies capable of neutralizing each of said intact differing influenza virus strain, said antigenic fragment being selected from the group of peptides consisting of:

  • Pro-Ser-Thr-Asp-Glu-Glu-Gln-Thr-Ser-Leu-Tyr-Val;

    Phe-Phe-Ser-Arg-Leu-Asn-Trp-Leu-Tyr-Lys-Ser-Gly-Ser-Thr-Tyr-Pro-Val-Leu;

    Ser-Lys-Ala-Phe-Ser-Asn-Ala-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-Ser-Leu; and

    Ala-Ala-Lys-Arg-Gly-Pro-Asp-Ser-Gly-(phenylalanine)-(phenylalanine)-Ser-Arg-Leu-Asp-Tyr-Leu-Thr-Lys-Ser-Gly-Ser-Thr-Thr-Pro-Val-Leu.

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